ArticleThe Journal of pediatrics2019
Associations of Growth and Body Composition with Brain Size in Preterm Infants.
Article in The Journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Body Composition of Infants Born with Intrauterine Growth Restriction: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- Neonatal steroid exposure and body composition in preterm infants at discharge.Pediatric research · 2026Article
- Fat-free mass is associated with neurodevelopment outcomes in extremely preterm infants up to 3 years of age.Pediatric research · 2026Article
- Bedside ultrasound imaging to measure muscle cross-sectional area in preterm and term infants: a feasibility study.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- [Neuropsychological development in late preterm infants: the potential role of parent-child interaction].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Towards improving outcomes: Protein, body composition, and brain development in preterm infants.Pediatric research · 2026Article
- Neonatal malnutrition, body composition, and childhood obesity in critically ill infants.Maternal health, neonatology and perinatology · 2025Article
- Standardizing Neonatal Body Composition Assessment Using Air Displacement Plethysmography: Insights from the Bavarian Experience.Children (Basel, Switzerland) · 2025Article
- Expanding diversity in developmental profiles of very-low-birth-weight infants during 6 years after birth.Scientific reports · 2025Article
- Association between Enteral Protein Intake and Fat-Free Mass Accretion in Very Preterm Infants.Neonatology · 2025Observational
- Lactoferrin intake from maternal milk during the neonatal hospitalization and early brain development among preterm infants.Pediatric research · 2024Article
- Expected and Desirable Preterm and Small Infant Growth Patterns.Advances in nutrition (Bethesda, Md.) · 2024Review
- Targeting optimal protein delivery in parenteral and enteral nutrition for preterm infants: a review of randomized, controlled trials.Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- Does faster weight trajectory lead to improved neurodevelopmental outcomes in ELBW infants with bronchopulmonary dysplasia?Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Infant body composition: A comprehensive overview of assessment techniques, nutrition factors, and health outcomes.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2023Review
- Correlation of NICU anthropometry in extremely preterm infants with brain development and language scores at early school age.Scientific reports · 2023Article
- Body composition measurement for the preterm neonate: using a clinical utility framework to translate research tools into clinical care.Journal of perinatology : official journal of the California Perinatal Association · 2022Review
- Associations of body composition with regional brain volumes and white matter microstructure in very preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2022Observational
- Intestinal Inflammation is Significantly Associated With Length Faltering in Preterm Infants at Neonatal Intensive Care Unit Discharge.Journal of pediatric gastroenterology and nutrition · 2022Article
- A Role for Data Science in Precision Nutrition and Early Brain Development.Frontiers in psychiatry · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo assess the association of very preterm infants' brain size at term-equivalent age with physical growth from birth to term and body composition at term. STUDY
designWe studied 62 infants born at <33 weeks of gestation. At birth and term, we measured weight and length and calculated body mass index. At term, infants underwent air displacement plethysmography to determine body composition (fat and fat-free mass) and magnetic resonance imaging to quantify brain size (bifrontal diameter, biparietal diameter, transverse cerebellar distance). We estimated associations of physical growth (Z-score change from birth to term) and body composition with brain size, adjusting for potential confounders using generalized estimating equations.
resultsThe median gestational age was 29 weeks (range, 24.0-32.9 weeks). Positive gains in weight and body mass index Z-score were associated with increased brain size. Each additional 100 g of fat-free mass at term was associated with larger bifrontal diameter (0.6 mm; 95% CI, 0.2-1.0 mm), biparietal diameter (0.7 mm; 95% CI, 0.3-1.1 mm), and transverse cerebellar distance (0.3 mm; 95% CI, 0.003-0.5 mm). Associations between fat mass and brain metrics were not statistically significant.
conclusionsWeight and body mass index gain from birth to term, and lean mass-but not fat-at term, were associated with larger brain size. Factors that promote lean mass accrual among preterm infants may also promote brain growth.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.