Evidence map›Paper›PMID 31376501›Full record

Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2020

The Differential Contribution of the Components of Parent-Child Interaction Therapy Emotion Development for Treatment of Preschool Depression.

Joan L Luby, Kirsten Gilbert, Diana Whalen, Rebecca Tillman, Deanna M Barch

2 registry-linked trialsAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02076425 nacompletednot on this map

A Randomized Controlled Trial of PCIT-ED for Preschool Depression

TypeinterventionalSponsorWashington University School of MedicineRan2014 to 2018Enrolled229ConditionsDepressive Disorder, MajorArmsPCIT-ED
NCT04399629 nacompletednot on this map

Preschool Based Prevention Targeting Emotion Development in Young Children Facing Adversity

TypeinterventionalSponsorWashington University School of MedicineRan2019 to 2021Enrolled62ConditionsChildhood Mental DisorderArmsPCIT-ED, Parenting Wisely
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
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  8. Article
  9. Article
  10. Asking Preadolescents About Suicide Is Not Associated With Increased Suicidal Thoughts.Journal of the American Academy of Child and Adolescent Psychiatry · 2026
    Article
  11. Social Determinants of Health, the developing brain, and risk and resilience for psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Preschool Mood Disorders: A Review of the Literature from 2017 to 2024.Child and adolescent psychiatric clinics of North America · 2025
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Joan L LubyWashington University School of Medicine, St. Louis, Missouri. Electronic address: lubyj@wustl.edu.
Kirsten GilbertWashington University School of Medicine, St. Louis, Missouri.
Diana WhalenWashington University School of Medicine, St. Louis, Missouri.
Rebecca TillmanWashington University School of Medicine, St. Louis, Missouri.
Deanna M BarchWashington University School of Medicine, St. Louis, Missouri.

Funding

A RANDOMIZED CONTROLLED TRIAL OF PCIT-ED FOR PRESCHOOL DEPRESSIONR01MH098454 · NIMH · WASHINGTON UNIVERSITY · PI BARCH, DEANNA, LUBY, JOAN L. · 2013 to 2017
$4.6M
Influence of Physical Activity on Daily Positive Affect & Affective Neural Activity in PreschoolersK23MH118426 · NIMH · WASHINGTON UNIVERSITY · PI WHALEN, DIANA J · 2018 to 2022
$879k
Heightened Performance Monitoring and Overcontrol: Neural Markers and Caregiving Processes in Developmental Risk TrajectoriesK23MH115074 · NIMH · WASHINGTON UNIVERSITY · PI GILBERT, KIRSTEN · 2017 to 2021
$821k
NIMH NIH HHS K23 MH115074NIMH NIH HHS K23 MH118426NIMH NIH HHS L30 MH108015NIMH NIH HHS R01 MH098454
6 · The paper itself

Abstract

objectiveAn adaptation of Parent-Child Interaction Therapy (PCIT) with a novel Emotion Development (ED) module has shown efficacy for the treatment of early childhood depression. Children who received PCIT-ED also showed healthy alterations in neural response to reward. We investigated whether the novel ED module made a unique contribution to the treatment of depression and neural response to reward, and whether child-directed intervention (CDI) and parent-directed intervention (PDI) modules (standard elements of PCIT) were also effective.

methodDyads who participated in a randomized controlled trial of PCIT that compared the active PCIT-ED to a wait list (WL) condition were assessed at the completion of each module of PCIT-ED (CDI, PDI, ED) or WL time equivalent for child depression and other symptoms, parenting styles, stress, and depression. Event-related potentials during a reward task were obtained at the end of standard PCIT and after the novel ED module.

resultsStudy findings showed that the ED module as well as some elements of standard PCIT were effective in reducing child depression and other forms of psychopathology. Changes in the child's neural response to reward and parental response to child emotional expression were specific to the ED module.

conclusionStudy findings suggest that the novel ED module has added efficacy for the treatment of early childhood depression, as well as unique efficacy in changing neural responses to reward and parenting response to child emotional expression. These findings can inform clinical uses of this treatment in a modular fashion. Future studies are needed that control for session number and order of PCIT-ED modules. CLINICAL TRIAL REGISTRATION INFORMATION: A Randomized Controlled Trial of PCIT-ED for Preschool Depression; https://clinicaltrials.gov/; NCT02076425.

Indexed as

DepressionParent-Child RelationsChildChild, PreschoolEmotionsEvoked PotentialsHumansParentsaffective symptomsdepressionpreschooltherapeutics

Identifiers

PMID31376501
PMCPMC6992503

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.