Evidence map›Paper›PMID 31376483›Full record

ReviewResearch in microbiology

Roles of FtsEX in cell division.

Sebastien Pichoff, Shishen Du, Joe Lutkenhaus

Open access · greenAbstract readReview
In one paragraph

Review in Research in microbiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 66 citations in OpenAlex.

  1. Control of cell division by anbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
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  5. Unique growth and morphology properties of Clade 5bioRxiv : the preprint server for biology · 2025
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  6. Review
  7. Article
  8. Article
  9. Review
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  12. Outer membrane barrier impairment byMicrobiology (Reading, England) · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Comparative genomics ofFrontiers in microbiology · 2024
    Article
  17. Article
  18. Article
  19. Mechanistic insights into the regulation of cell wall hydrolysis by FtsEX and EnvC at the bacterial division site.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sebastien PichoffDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Shishen DuDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Joe LutkenhausDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS, 66160, USA. Electronic address: jlutkenh@kumc.edu.
University of Kansas Medical Center · US

Funding

REGULATION OF EXPRESSION OF CELL DIVISION GENESR01GM029764 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI LUTKENHAUS, JOSEPH F · 1985 to 2022
$4.2M
NIGMS NIH HHS R01 GM029764
6 · The paper itself

Abstract

FtsEX is a member of a small subclass of ABC transporters that uses mechano-transmission to perform work in the periplasm. FtsEX controls periplasmic peptidoglycan (PG) hydrolase activities in many Gram negative and positive organisms to ensure the safe separation of daughter cells during division. In these organisms FtsEX localizes to the Z ring and uses its ATPase activity to regulate its periplasmic effectors. In Escherichia coli, FtsEX also participates in building the divisome and coordinates PG synthesis with PG hydrolysis. This review discusses studies that are beginning to elucidate the mechanisms of FtsEX's various roles in cell division.

Indexed as

ATP-Binding Cassette TransportersBiomechanical PhenomenaCell Cycle ProteinsCell DivisionCell WallCystic Fibrosis Transmembrane Conductance RegulatorEscherichia coliEscherichia coli ProteinsN-Acetylmuramoyl-L-alanine AmidasePeptidoglycanATP-Binding Cassette TransportersCell Cycle ProteinsCystic Fibrosis Transmembrane Conductance RegulatorEscherichia coli ProteinsFtsE protein, E coliFtsX protein, E coliN-Acetylmuramoyl-L-alanine AmidasePeptidoglycanABC transporterDivisomeFtsEXPeptidoglycan hydrolyasesZ ring

Identifiers

PMID31376483
PMCPMC6899183
OpenAlexW2966240922

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.