Evidence map›Paper›PMID 31376471›Full record

ArticleRespiratory physiology & neurobiology2019

Heart rate variability and heart rate recovery in lung cancer survivors eligible for long-term cure.

Duc Ha, Atul Malhotra, Andrew L Ries, Wesley T O'Neal, Mark M Fuster

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory physiology & neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05179408 (Telerehabilitation for Veteran Lung Cancer Survivors Following Curative Intent Therapy), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05179408 narecruitingnot on this mapstarted 2026, after this paper: background citation

Telerehabilitation for Veteran Lung Cancer Survivors Following Curative Intent Therapy

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2026 to 2027Enrolled40ConditionsLung Cancer, Cancer SurvivorsArmsTargeted-telerehabilitation, Waitlist
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Survivorship Challenges and Supportive Care in Lung Cancer.Seminars in respiratory and critical care medicine · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Toward Modernization of Geriatric Oncology by Digital Health Technologies.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2020
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Duc HaInstitute for Health Research, Kaiser Permanente Colorado, Aurora, Colorado, USA; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California, USA. Electronic address: duc.m.ha@kp.org.
Atul MalhotraDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Andrew L RiesDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Wesley T O'NealDivision of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Mark M FusterDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California, USA; Section of Pulmonary and Critical Care Medicine, VA San Diego Healthcare System, San Diego, California, USA.
University of California San Diego · USEmory University · USKaiser Permanente · US

Funding

Training in the Next Generation in Respiratory ScienceT32HL134632 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, POWELL, FRANK L. · 2017 to 2021
$2.1M
Training in Respiratory Biology: Innovate, Integrate, and TranslateT32HL098062 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI POWELL, FRANK L. · 2010 to 2014
$2.1M
Aging Influence on the Development of Sleep ApneaK23AG024837 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI MALHOTRA, ATUL · 2004 to 2007
$730k
Glycocalyx Targeting and Augmenting Cellular Immunity in Lung CancerI01BX003688 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI FUSTER, MARK M · 2018 to 2025
–
BLRD VA I01 BX003688EPA EP-D-17-020NCI NIH HHS L30 CA208950NHLBI NIH HHS T32 HL098062NHLBI NIH HHS T32 HL134632NIA NIH HHS K23 AG024837
6 · The paper itself

Abstract

Lung cancer survivors are at risk for physical fitness and autonomic function impairments. In a cross-sectional study of consecutive lung cancer survivors post-curative intent therapy, we assessed and identified predictors of resting heart rate variability (HRV) and heart rate recovery (HRR), defined as standard deviation of normal-to-normal-R-to-R intervals (SDNN) and root-mean-square-of-successive-differences (rMSSD) from routine outpatient single 10-s electrocardiographs (ECGs) and difference in heart rate (HR) at 1-minute following and the end of the six-minute-walk-test (6MWT), respectively. In 69 participants, the mean (SD) HRR was -10.6 (6.7) beats. Significant independent predictors of HRR were age and HR change associated with the 6MWT. In a subset of 41 participants with available ECGs, the mean (SD) SDNN and rMSSD were 19.1 (15.6) and rMSSD 18.2 (14.6) ms, respectively. Significant independent predictors of HRV were supine HR, HRR, and total lung capacity. HRV/HRR may be useful physiological measures in studies aimed at improving physical fitness and/or autonomic function in lung cancer survivors.

Indexed as

Cancer SurvivorsAgedAutonomic Nervous SystemCross-Sectional StudiesExercise TestFemaleHeart RateHumansLung NeoplasmsMaleMiddle AgedPhysical FitnessAutonomic nervous systemLung neoplasmsPhysical fitnessSurvivorship

Identifiers

PMID31376471
PMCPMC6759398
OpenAlexW2965884026

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.