ArticleThe European journal of neuroscience2020
The ventrolateral periaqueductal grey updates fear via positive prediction error.
Article in The European journal of neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Optogenetic stimulation of Purkinje cells in the cerebellar vermis disrupts innate freezing behaviors and is highly aversive.bioRxiv : the preprint server for biology · 2026Article
- The Periaqueductal Gray Selectively Supports Reversal Learning During a Flexible Discrimination Task in Mice.bioRxiv : the preprint server for biology · 2026Article
- Paraventricular thalamic inputs to the ventral pallidum shape reward seeking during threat and fear responding in extinction.Behavioral neuroscience · 2025Article
- Molecular Aspects of Geriatric Pharmacotherapy.Cells · 2025Review
- Short-term synaptic dynamics in the ventrolateral and dorsomedial periaqueductal gray.bioRxiv : the preprint server for biology · 2025Article
- No effect of partial reinforcement on fear extinction learning and memory in C57BL/6J mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2025Article
- The Spiraling Cognitive-Emotional Brain: Combinatorial, Reciprocal, and Reentrant Macro-organization.Journal of cognitive neuroscience · 2024Article
- Multiple Posterior Insula Projections to the Brainstem Descending Pain Modulatory System.International journal of molecular sciences · 2024Article
- Translational approaches to the neurobiological study of conditional discrimination and inhibition: Implications for psychiatric disease.Behavioral neuroscience · 2024Review
- Climbing Fiber Activation Induced by Footshock in the Cerebellar Vermis Lobule IV/V of Freely Moving Mice.Physiological research · 2024Article
- Noncortical cognition: integration of information for close-proximity behavioral problem-solving.Current opinion in behavioral sciences · 2024Article
- Conditioned inhibition of fear and reward in male and female rats.Neurobiology of learning and memory · 2024Article
- Optogenetic inhibition of the caudal substantia nigra inflates behavioral responding to uncertain threat and safety.Behavioral neuroscience · 2023Article
- Article
- Optogenetic inhibition of the caudal substantia nigra inflates behavioral responding to uncertain threat and safety.bioRxiv : the preprint server for biology · 2023Article
- Dynamic causal modeling reveals increased cerebellar- periaqueductal gray communication during fear extinction.Frontiers in systems neuroscience · 2023Article
- Cerebellar contribution to threat probability in a SCA6 mouse model.Human molecular genetics · 2022Article
- Brainstem networks construct threat probability and prediction error from neuronal building blocks.Nature communications · 2022Article
- Sparse genetically defined neurons refine the canonical role of periaqueductal gray columnar organization.eLife · 2022Article
- Article
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Abstract
Aversive, positive prediction error (+PE) provides a mechanism to update and increase future fear to uncertain threat predictors. The ventrolateral periaqueductal grey (vlPAG) has been offered as a neural locus for +PE computation. Yet, a causal demonstration of vlPAG +PE activity to update fear remains elusive. We devised a fear discrimination procedure in which a danger cue predicts shock deterministically and an uncertainty cue predicts shock probabilistically, requiring prediction errors to achieve an appropriate fear response. Recording vlPAG single-unit activity during fear discrimination in Long-Evans rats, we reveal activity related to shock is consistent with +PE and updates subsequent fear to uncertainty at the trial level. We further demonstrate that vlPAG inhibition during shock selectively decreases future fear to uncertainty, but not danger, and temporal emergence of this effect is consistent with single-unit activity. These findings provide causal evidence that vlPAG +PE is necessary for fear updating.
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