SynthesisActa obstetricia et gynecologica Scandinavica2020
Early-onset fetal growth restriction: A systematic review on mortality and morbidity.
Synthesis in Acta obstetricia et gynecologica Scandinavica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- The Effect of Maternal Haemoglobinopathies and Iron Deficiency Anaemia on Foetal Growth Restriction: A Systematic Review and Meta-Analysis.Maternal & child nutrition · 2025Pooled it
- Early-onset fetal growth restriction: A systematic review on mortality and morbidity.Acta obstetricia et gynecologica Scandinavica · 2020Pooled it
- Neonatal Adverse Outcomes of Induction and Expectant Management in Fetal Growth Restriction: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2020Pooled it
- The SAVE FGR study: Short term variation Analysis versus Visual Evaluation of cardiotocography in early-onset Fetal Growth Restriction to trigger expedited birth - study protocol for a stepped wedge cluster randomized trial.BMC pregnancy and childbirth · 2026Trial
- Maternal Sildenafil vs Placebo in Pregnant Women With Severe Early-Onset Fetal Growth Restriction: A Randomized Clinical Trial.JAMA network open · 2020Trial
- Modified umbilical artery Doppler scoring system based on multisite assessment: association with perinatal outcome in early and late fetal growth restriction.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026Article
- The TRUFFLE monitoring protocol for early-onset fetal growth restriction: A clinical effectiveness study.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Moderate Diagnostic Yield of Exome Sequencing in Fetal Growth Restriction: Retrospective Insights.Prenatal diagnosis · 2026Article
- A rapid review of genetic association studies of parent-of-origin effects and fetal growth.Molecular and cellular pediatrics · 2026Review
- Correlations Between Pregnancy-Associated Plasma Protein A Levels and Pregnancy Characteristics, Placental Volume, Vascularization, and Histopathology.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2026Article
- Planned mode of delivery and neonatal outcomes in pregnancies complicated by late-onset fetal growth restriction: a retrospective cohort study.Archives of gynecology and obstetrics · 2026Article
- Temporal Changes in Fetal and Maternal Parameters in Early-Onset Fetal Growth Restriction: A Multicenter, Retrospective Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Research progress of cerebroplacental ratio in obstetric complications.Frontiers in medicine · 2026Review
- Impact of hypertensive disorders on disease progression in pregnancies affected by early-onset fetal growth restriction.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Stillbirths: Contribution of preterm birth and size-for-gestational age for 125.4 million total births from nationwide records in 13 countries, 2000-2020.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Perinatal risk assessment in pregnancies complicated by early-onset fetal growth restriction: development and internal validation of a prediction model for composite adverse perinatal outcome.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025Article
- New first trimester circulating angiogenic biomarkers in predicting early-onset and late-onset fetal growth restriction: a case-control study.BMC pregnancy and childbirth · 2025Article
- The impact of cannabinoids on reproductive function.Reproduction (Cambridge, England) · 2025Review
- Quantifying prenatal and postnatal mortality in extreme early onset fetal growth restriction: A systematic review and incidence analysis.Pregnancy (Hoboken, N.J.) · 2025Review
- Insights into the Global and Mexican Context of Placental-Derived Pregnancy Complications.Biomedicines · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSevere early-onset fetal growth restriction is an obstetric condition with significant risks of perinatal mortality, major and minor neonatal morbidity, and long-term health sequelae. The prognosis of a fetus is influenced by the extent of prematurity and fetal weight. Clinical care is individually adjusted. In literature, survival rates vary and studies often only include live-born neonates with missing rates of antenatal death. This systematic review aims to summarize the literature on mortality and morbidity. MATERIAL AND
methodsA broad literature search was conducted in OVID MEDLINE from 2000 to 26 April 2019 to identify studies on fetal growth restriction and perinatal death. Studies were excluded when all included children were born before 2000 because (neonatal) health care has considerably improved since this period. Studies were included that described fetal growth restriction diagnosed before 32 weeks of gestation and antenatal mortality and neonatal mortality and/or morbidity as outcome. Quality of evidence was rated with the GRADE instrument.
resultsOf the 2604 publications identified, 25 studies, reporting 2895 pregnancies, were included in the systematic review. Overall risk of bias in most studies was judged as low. The quality of evidence was generally rated as very low to moderate, except for 3 large well-designed randomized controlled trials. When combining all data on mortality, in 355 of 2895 pregnancies (12%) the fetus died antenatally, 192 died in the neonatal period (8% of live-born neonates) and 2347 (81% of all pregnancies) children survived. Of the neonatal morbidities recorded, respiratory distress syndrome (34% of the live-born neonates), retinopathy of prematurity (13%) and sepsis (30%) were most common. Of 476 children that underwent neurodevelopmental assessment, 58 (12% of surviving children, 9% of all pregnancies) suffered from cognitive impairment and/or cerebral palsy.
conclusionsWhen combining the data of 25 included studies, survival in fetal growth restriction pregnancies, diagnosed before 32 weeks of gestation, was 81%. Neurodevelopmental impairment was assessed in a minority of surviving children. Individual prognostic counseling on the basis of these results is hampered by differences in patient and pregnancy characteristics within the included patient groups.
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