ArticleJournal of clinical hypertension (Greenwich, Conn.)2019
Nocturnal dipping status and the association of morning blood pressure surge with subclinical target organ damage in untreated hypertensives.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 26 citations in OpenAlex.
- Blood pressure variability in daily life: comparing individuals with cervical and upper-thoracic spinal cord injury to non-injured controls.Journal of human hypertension · 2026Article
- Blood pressure determinants of target organ damage among adults with white coat hypertension with a focus on nocturnal hypertension and blood pressure dipping.Journal of human hypertension · 2026Article
- Ambulatory blood pressure monitoring in arterial hypertension.Internal and emergency medicine · 2026Review
- Characteristic of 24-Hour Blood Pressure Dipping Patterns in Hypertensive Stroke Patients.Vascular health and risk management · 2024Article
- Different Factors Associated with Morning Blood Pressure Surge in Antihypertensive-Naïve Dipper and Non-Dipper Subjects.Journal of clinical medicine · 2023Article
- Difference between morning and evening home blood pressure and cardiovascular events: the J-HOP Study (Japan Morning Surge-Home Blood Pressure).Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Reproducibility study of nocturnal blood pressure dipping in patients with high cardiovascular risk.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Vitamin D Deficiency in Children With Vasovagal Syncope Is Associated With Impaired Circadian Rhythm of Blood Pressure.Frontiers in neuroscience · 2021Article
- Peak blood pressure-guided monitoring may serve as an effective approach for blood pressure control in the out-of-office setting.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Afternoon blood pressure increase on home blood pressure measurement: A forgotten entity?Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Nocturnal blood pressure patterns and cardiac damage: there is still much to learn.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Observational
- Nocturnal dipping status and the association of morning blood pressure surge with subclinical target organ damage in untreated hypertensives.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Possible interesting link between dipping status and morning surge for subclinical target organ damage in hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The authors aimed to investigate the association between sleep-through morning surge (MS) in blood pressure (BP) and subclinical target organ damage in untreated hypertensives with different nocturnal dipping status. This cross-sectional study included 1252 individuals who underwent anthropometric measurements, serum biochemistry evaluation, 24-hour ambulatory blood pressure monitoring, echocardiography, and carotid ultrasonography. Left ventricular mass index, left atrial dimension, and carotid intima-media thickness were evaluated. Participants were grouped according to nocturnal systolic BP dipping rate (388 dippers, 10%-20%; 674 non-dippers, 0%-10%; 190 reverse dippers, <0%). Twenty-two extreme dippers were excluded. While reverse dippers exhibited the most severe signs of damage, only dippers showed significant and positive correlation between MS and hypertension-mediated organ damage (all P < .05), with significant area under the receiver operating characteristic curve for discriminating left ventricular hypertrophy (0.662), left atrial enlargement (0.604), and carotid intima-media thickening (left, 0.758; right, 0.726; all P < .05). MS showed significant association with subclinical organ damage on both logistic and multiple linear regression analysis adjusted for age, sex, body mass index, smoking status, and alcohol consumption status, as well as for the levels of fasting blood glucose, uric acid, serum creatinine, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol, even when 24-hour, daytime, nocturnal, and morning systolic BP were included (odds ratio >1 and P < .01 for all types of damage). Besides race, nocturnal dipping status might affect the role of MS in subclinical target organ damage, with a significant association only in dippers, independent of other systolic BP parameters. Dipping status might account for the discrepancies across previous reports.
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