ArticleBrain imaging and behavior2020
Abnormal synchronization of functional and structural networks in schizophrenia.
Article in Brain imaging and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Brain functional network correlates and predictors of the perioperative antidepressant effect of esketamine in breast cancer patients: a double-blind randomized controlled trial using resting-state fMRI and graph theory.Translational psychiatry · 2026Trial
- Neural mechanism underlying the beneficial effect of Theory of Mind psychotherapy on early-onset schizophrenia: a randomized controlled trial.Journal of psychiatry & neuroscience : JPNTrial
- Review
- A Method for Estimating Dynamic Functional Network Connectivity Gradients (dFNGs) From ICA Captures Smooth Inter-Network Modulation.Human brain mapping · 2025Article
- Abnormal brain network reconfiguration in neuropsychiatric disorders across cognitive decline, Depression, and Schizophrenia.PloS one · 2025Article
- Characterization of the white matter networks in schizophrenia patients with metabolic syndrome undergoing risperidone or clozapine treatment.Frontiers in neuroscience · 2025Article
- Interdisciplinary Approaches in Psychiatric Research: From Neural Dynamics to Clinical Applications in Schizophrenia.Actas espanolas de psiquiatria · 2025Article
- Article
- Altered functional brain networks in coronary heart disease: independent component analysis and graph theoretical analysis.Brain structure & function · 2024Article
- Bridging functional and anatomical neural connectivity through cluster synchronization.Scientific reports · 2023Article
- Diagnosis of Chronic Musculoskeletal Pain by Using Functional Near-Infrared Spectroscopy and Machine Learning.Bioengineering (Basel, Switzerland) · 2023Article
- Through the looking glass: Deep interpretable dynamic directed connectivity in resting fMRI.NeuroImage · 2022Article
- Alterations in TRN-anterodorsal thalamocortical circuits affect sleep architecture and homeostatic processes in oxidative stress vulnerable GclmMolecular psychiatry · 2022Article
- Alterations in white matter network dynamics in patients with schizophrenia and bipolar disorder.Human brain mapping · 2022Article
- Graph Convolutional Networks Reveal Network-Level Functional Dysconnectivity in Schizophrenia.Schizophrenia bulletin · 2022Article
- Multiscale Weighted Permutation Entropy Analysis of Schizophrenia Magnetoencephalograms.Entropy (Basel, Switzerland) · 2022Article
- Method for persistent topological features extraction of schizophrenia patients' electroencephalography signal based on persistent homology.Frontiers in computational neuroscience · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Synchronization is believed to play an important role in information processing of the brain. Mounting evidence supports the hypothesis that schizophrenia is related to impaired neural synchrony. However, most previous studies characterize brain synchronization from the perspective of temporal coordination of distributed neural activity, rather than network properties. Our aim was to investigate the network synchronization alterations in schizophrenia using publically available data. Resting-state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) were performed in 96 schizophrenia patients and 120 healthy controls. The whole-brain functional and structural networks were constructed and analyzed using graph theoretical approaches. Inter-group differences in network synchronization were investigated. Both the binary and weighted functional networks of schizophrenia patients exhibited decreased synchronizability (increased eigenratio) than those of healthy controls. With respect to the structural binary networks, schizophrenia patients showed a trend towards excessive synchronizability (decreased eigenratio). In addition, the excessive synchronizability of the structural binary networks was associated with more severe negative symptoms in schizophrenia patients. Our findings provide novel biological evidence that schizophrenia involves a disruption of neural synchrony from the perspective of network properties.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.