ArticleNeurochemical research2019
Experimental Characterization of the Chronic Constriction Injury-Induced Neuropathic Pain Model in Mice.
Article in Neurochemical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Peripheral somatostatin-expressing neurons are analgesic targets for refractory occipital neuralgia.Acta pharmacologica Sinica · 2026Article
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- Validation of Paw Skin Hyperspectral Imaging for Assessing Neuropathic Pain Severity in a Chronic Constriction Injury Model.International journal of molecular sciences · 2026Article
- Article
- Article
- Neuropathic pain after peripheral nerve injury in rats: a model using sciatic nerve clamping.Journal of anesthesia · 2025Article
- Deciphering the effects of polydatin on neuropathic pain and motor performance in a chronic constriction injury model: role of GABA and opioid receptors and neuroprotective properties.Frontiers in pharmacology · 2025Article
- Sinomenine Ameliorated Microglial Activation and Neuropathic Pain After Chronic Constriction Injury Via TGF-β1/ALK5/Smad3 Signalling Pathway.Journal of cellular and molecular medicine · 2024Article
- Glutamatergic systems in neuropathic pain and emerging non-opioid therapies.Pharmacological research · 2022Review
- Inhibition of Schwann cell pannexin 1 attenuates neuropathic pain through the suppression of inflammatory responses.Journal of neuroinflammation · 2022Article
- Protein Tyrosine Phosphatase Receptor Type D Regulates Neuropathic Pain After Nerve InjuryFrontiers in molecular neuroscience · 2022Article
- Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic pain.Scientific reports · 2021Article
- Article
- The antioxidant N-(2-mercaptopropionyl)-glycine (tiopronin) attenuates expression of neuropathic allodynia and hyperalgesia.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Zerumbone-Induced Analgesia Modulated via Potassium Channels and Opioid Receptors in Chronic Constriction Injury-Induced Neuropathic Pain.Molecules (Basel, Switzerland) · 2020Article
- Zerumbone Modulates αFrontiers in pharmacology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
Number of ligations made in the chronic constriction injury (CCI) neuropathic pain model has raised serious concerns. We compared behavioural responses, nerve morphology and expression of pain marker, c-fos among CCI models developed with one, two, three and four ligations. The numbers of ligation(s) on sciatic nerve shows no significant difference in displaying mechanical and cold allodynia, and mechanical and thermal hyperalgesia throughout 84 days. All groups underwent similar levels of nerve degeneration post-surgery. Similar c-fos level in brain cingulate cortex, parafascicular nuclei and amygdala were observed in all CCI models compared to sham-operated group. Therefore, number of ligations does not impact intensity of pain symptoms, pathogenesis and neuronal activation. A single ligation is sufficient to develop neuropathic pain, in contrast to the established model of four ligations. This study dissects and characterises the CCI model, ascertaining a more uniform animal model to surrogate actual neuropathic pain condition.
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