ArticleAnnals of surgical oncology2019
Adolescents and Young Adults with Breast Cancer have More Aggressive Disease and Treatment Than Patients in Their Forties.
Article in Annals of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
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69 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Breast malignancy in female-to-male transsexuals: systematic review, case report, and recommendations for screening.Breast (Edinburgh, Scotland) · 2020Pooled it
- Contrast-enhanced mammography versus breast MRI in the preoperative evaluation of the nipple-areola complex: data from a real-world setting.European radiology · 2026Article
- The motherhood role expectations for young female patients with breast cancer: a qualitative study.Frontiers in global women's health · 2026Article
- The incidence, clinicopathological characteristics and the survival outcomes among young breast cancer patients in Alexandria, Egypt.Ecancermedicalscience · 2026Article
- Adolescent Girls' Breast Self-Examination Practices in Eastern Region of Ghana.The breast journal · 2026Article
- Healthcare professionals' perspectives on the reproductive management of young women with breast cancer: A qualitative study based on social-ecological system theory.Asia-Pacific journal of oncology nursing · 2025Article
- Correlation between ultrasonography and elastography parameters and molecular subtypes of breast cancer in young women.Annals of medicine · 2025Article
- Article
- Comparative Effectiveness of Direct Oral Anticoagulants and Warfarin on Venous Thromboembolism in Cancer Patients.Cancer medicine · 2025Article
- Proteogenomic characterization of invasive breast tumors in young women.NPJ breast cancer · 2025Article
- National trends in neoadjuvant systemic therapy utilization in patients with early-stage HER2-positive breast cancer from 2016-2021: The impact of the KATHERINE trial.Breast cancer research and treatment · 2025Article
- Correlation between multimodality imaging features and molecular subtypes in breast cancer: a comparative study between young (≤30 years) and middle-aged (45-55 years) women.Quantitative imaging in medicine and surgery · 2025Article
- A nomogram for predicting overall survival in young triple-negative breast cancer patients: a population-based study.Discover oncology · 2025Article
- Article
- Long-term health-related quality of life among adolescent and young adult breast cancer survivors.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Receipt of guideline-concordant care and survival among young adult women with non-metastatic breast cancer.Breast cancer research and treatment · 2025Article
- Trajectories of antidepressant use after tamoxifen initiation among young and middle-aged women with breast cancer.Breast cancer research and treatment · 2025Article
- Article
- Unveiling the Clinicopathological Outcomes of Breast Cancer in Young Women:Sultan Qaboos University medical journal · 2025Article
- Prognostic nomograms for young breast cancer: A retrospective study based on the SEER and METABRIC databases.Cancer innovation · 2024Review
9 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdolescents and young adults (AYAs; age < 40 years) account for less than 2% of breast cancer patients. Therefore, little is known about the tumor characteristics and care provided to AYA patients. This study sought to describe demographic, tumor, and treatment variables among AYA patients.
methodsThe study identified patients ages 15 to 49 years with breast cancer between 2010 and 2015 from the National Cancer Database. Patient and tumor factors were compared using Chi-square tests. Multivariable logistic regression was used to model the effect of age group on treatment while adjusting for confounding variables.
resultsThe study identified 46,265 AYA patients with stages 0 to 3 breast cancer and compared them with 169,423 breast cancer patients ages 40 to 49 years. A greater proportion of the AYA patients presented with clinical stage 2 or 3 disease than the adult patients 40 to 49 years old (stage 2 disease: 44.3% vs 29.9%, respectively; stage 3 disease: 14.0% vs 7.7%, respectively; both p < 0.001). A greater proportion of the AYA patients had triple-negative breast cancer (TNBC) or human epidermal growth factor receptor 2-positive (HER2+) cancer than the adult patients (TNBC: 21.2% vs 13.8%, respectively; HER2+: 26.0% vs 18.6%, respectively; both p < 0.001). Among the AYA patients, the very young (ages 15-29 years) had more advanced disease and TNBC or HER2+ disease than the older youth (ages 30 to 39 years). The multivariable analysis showed that the AYA patients were more likely to undergo mastectomy (odds ratio [OR] 2.1) and receive chemotherapy (OR 1.9) than patients in their forties (both p < 0.001).
conclusionA greater proportion of the AYA breast cancer patients had more advanced disease and TNBC and HER2+ disease. The AYA patients had higher rates of mastectomy and use of chemotherapy than the adult breast cancer patients, reflecting that more aggressive therapy is recommended or chosen for women in this age group.
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