ArticleExtremophiles : life under extreme conditions2019
A novel thermophilic Aeribacillus bacteriophage AP45 isolated from the Valley of Geysers, Kamchatka: genome analysis suggests the existence of a new genus within the Siphoviridae family.
Article in Extremophiles : life under extreme conditions, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Bacteriophages of Thermophilic 'International journal of molecular sciences · 2024Pooled it
- Molecular characterization, identification and enzyme-producing potential of thermophilic bacterial diversity isolated from the Kars sugar factory.BMC microbiology · 2025Article
- Biological Characterization and Genomic Analysis of Three NovelInternational journal of molecular sciences · 2024Article
- Characterization of a Thermostable Endolysin of theViruses · 2024Article
- Characterization and Genome Study of a Newly Isolated Temperate Phage Belonging to a New Genus TargetingGenes · 2023Article
- Bacteriophages of Thermophilic 'Microorganisms · 2021Review
- Microbiology research at the systems biology and bioinformatics - 2019 (SBB-2019) school.BMC microbiology · 2020Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
A novel thermophilic bacteriophage AP45 and its host strain Aeribacillus sp. CEMTC656 were isolated from the Valley of Geysers, Kamchatka Peninsula, Russia. Bacteriophage AP45 was identified as a member of the Siphoviridae family by electron microscopy. It showed high thermostability and had a slow cycle of reproduction. The AP45 genome had 51,606 base pairs (bp) and contained 71 open reading frames (ORFs), 40 of them encoding proteins of predicted function. Genes encoding DNA and RNA polymerases were not identified, indicating that AP45 used host polymerases. Based on the ORF65 encoding putative endolysin, the recombinant protein rAP45Lys was developed and its peptidoglycan-hydrolyzing activity was demonstrated. The AP45 genome exhibited limited identity to other phage sequences; the highest identity, 36%, was with the genome of the thermophilic Geobacillus myovirus D6E. The majority of putative proteins encoded by the AP45 genome had higher similarity to proteins from bacteria belonging to the Bacillaceae family, than to bacteriophages. In addition, more than half of the putative ORFs in the AP45 genome were highly similar to prophage sequences of A. pallidus strain 8m3, which was isolated in north-east China. The AP45 phage and revealed prophages might be members of a new genus belonging to the Siphoviridae family.
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