ArticlePsychopharmacology2019
Sensitivity to negative and positive feedback as a stable and enduring behavioural trait in rats.
Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Reinforcement sensitivity phenotype modulates the impact of chronic stress on hedonic capacity in rats, but not the response to fluoxetine.Psychopharmacology · 2026Article
- A "personality test" for rats reveals subtle but distinct effects of sex and early life inflammation on brain and behavior.Behavioral neuroscience · 2026Article
- Importance of additional behavioral observation in psychopharmacology: a case study on agomelatine's effects on feedback sensitivity in probabilistic reversal learning in rats.Psychopharmacology · 2025Article
- A primer on the use of computational modelling to investigate affective states, affective disorders and animal welfare in non-human animals.Cognitive, affective & behavioral neuroscience · 2024Article
- Trait sensitivity to stress and cognitive bias processes in fish: A brief overview.Personality neuroscience · 2024Review
- Non-human contributions to personality neuroscience: From fish through primates - a concluding editorial overview.Personality neuroscience · 2024Article
- Trait sensitivity to positive feedback is a predisposing factor for several aspects of compulsive alcohol drinking in male rats: behavioural, physiological, and molecular correlates.Psychopharmacology · 2024Article
- Artificial selection for reversal learning reveals limited repeatability and no heritability of cognitive flexibility in great tits (Proceedings. Biological sciences · 2023Article
- Trait sensitivity to negative feedback in rats is associated with increased expression of serotonin 5-HTFrontiers in molecular neuroscience · 2023Article
- Trait sensitivity to negative feedback determines the effects of chronic stress and chronic mirtazapine treatment on anxiety and stress-coping strategies in rats.Psychopharmacology · 2022Article
- Noradrenergic regulation of two-armed bandit performance.Behavioral neuroscience · 2022Article
- Tolerance to neurochemical and behavioral effects of the hallucinogen 25I-NBOMe.Psychopharmacology · 2021Article
- Neurochemical and Behavioral Effects of a New Hallucinogenic Compound 25B-NBOMe in Rats.Neurotoxicity research · 2021Article
- Trait Sensitivity to Negative and Positive Feedback Does Not Interact With the Effects of Acute Antidepressant Treatment on Hedonic Status in Rats.Frontiers in behavioral neuroscience · 2020Article
- Trait sensitivity to negative feedback determines the intensity of compulsive alcohol seeking and taking in male rats.Journal of psychiatry & neuroscience : JPNArticle
- Comparison of conventional and rapid-acting antidepressants in a rodent probabilistic reversal learning task.Brain and neuroscience advancesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleAccording to psychological theories, cognitive distortions play a pivotal role in the aetiology and recurrence of mood disorders. Although clinical evidence for the coexistence of depression and altered sensitivity to performance feedback is relatively coherent, we still do not know whether increased or decreased sensitivity to positive or negative feedback is associated with 'pro-depressive' profile in healthy subjects.
objectiveOur research has been designed to answer this question, and here, we present the first steps in that direction.
methodsUsing a rat version of the probabilistic reversal-learning (PRL) paradigm, we evaluated how sensitivity to negative and positive feedback influences other cognitive processes associated with mood disorders, such as motivation in the progressive ratio schedule of reinforcement (PRSR) paradigm, hedonic status in the sucrose preference (SP) test, locomotor and exploratory activity in the open field (OF) test, and anxiety in the light/dark box (LDB) test.
resultsThe results of our study demonstrated for the first time that in rodents, sensitivity to negative and positive feedback could be considered a stable and enduring behavioural trait. Importantly, we also showed that these traits are independent of each other and that trait sensitivity to positive feedback is associated with cognitive flexibility in the PRL test. The computational modelling results also revealed that in animals classified as sensitive to positive feedback, the α learning rates for both positive and negative reward prediction errors were higher than those in animals classified as insensitive. We observed no statistically significant interactions between sensitivity to negative or positive feedback and the parameters measured in the PRSR, SP, OF or LDB tests.
conclusionsFurther studies using animal models of depression based on chronic stress should reveal whether sensitivity to feedback is a latent trait that when interacts with stressful life events, could produce correlates of depressive symptoms in rats.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.