Evidence map›Paper›PMID 31375749›Full record

ArticleScientific reports2019

Effect of flavor on neuronal responses of the hypothalamus and ventral tegmental area.

A M van Opstal, A A van den Berg-Huysmans, M Hoeksma, C Blonk, H Pijl, S A R B Rombouts, J van der Grond

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

A M van OpstalLeiden University Medical Center, Department of Radiology, Leiden, The Netherlands. a.m.van_opstal@lumc.nl.
A A van den Berg-HuysmansLeiden University Medical Center, Department of Radiology, Leiden, The Netherlands.
M HoeksmaUnilever Research & Development, Vlaardingen, The Netherlands.
C BlonkUnilever Research & Development, Vlaardingen, The Netherlands.
H PijlLeiden University Medical Center, Department of Internal Medicine, Section Endocrinology, Leiden, The Netherlands.
S A R B RomboutsLeiden University Medical Center, Department of Radiology, Leiden, The Netherlands.
J van der GrondLeiden University Medical Center, Department of Radiology, Leiden, The Netherlands.
Leiden University Medical Center · NLUnilever (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although it is well known that food intake is affected by the palatability of food, the actual effect of flavoring on regulation of energy-homeostasis and reward perception by the brain, remains unclear. We investigated the effect of ethyl-butyrate (EB), a common non-caloric food flavoring, on the blood oxygen level dependent (BOLD) response in the hypothalamus (important in regulating energy homeostasis) and ventral tegmental area (VTA; important in reward processes). The 16 study participants (18-25 years, BMI 20-23 kg/m

Indexed as

RewardAdministration, OralAdolescentAdultAnimalsButyratesCross-Over StudiesEatingEnergy MetabolismFlavoring AgentsGlucoseHealthy VolunteersHumansHypothalamusMagnetic Resonance ImagingMaleButyratesethyl butyrateFlavoring AgentsGlucose

Identifiers

PMID31375749
PMCPMC6677894
OpenAlexW2966175260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.