Evidence map›Paper›PMID 31375701›Full record

ArticleScientific reports2019

Reversibility of Age-related Oxidized Free NADH Redox States in Alzheimer's Disease Neurons by Imposed External Cys/CySS Redox Shifts.

Yue Dong, Sara Sameni, Michelle A Digman, Gregory J Brewer

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Changes in the brain [NADFrontiers in aging neuroscience · 2026
    Review
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  14. Whole-blood metabolomics of dementia patients reveal classes of disease-linked metabolites.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yue DongDepartment of Biomedical Engineering, University of California Irvine, Irvine, California, United States of America.
Sara SameniDepartment of Biomedical Engineering, University of California Irvine, Irvine, California, United States of America.
Michelle A DigmanDepartment of Biomedical Engineering, University of California Irvine, Irvine, California, United States of America.
Gregory J BrewerDepartment of Biomedical Engineering, University of California Irvine, Irvine, California, United States of America. gjbrewer@uci.edu.
University of California, Irvine · US

Funding

TRD4: Phasor analysisP41GM103540 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GRATTON, ENRICO · 2012 to 2020
$12.5M
Age-related metabolic alterations in amyloid processing in Alzheimer's diseaseRF1AG058218 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BREWER, GREGORY J, GLABE, CHARLES G. · 2018 to 2018
$2.9M
NIA NIH HHS RF1 AG058218NIGMS NIH HHS P41 GM103540
6 · The paper itself

Abstract

Redox systems including extracellular cysteine/cystine (Cys/CySS), intracellular glutathione/oxidized glutathione (GSH/GSSG) and nicotinamide adenine dinucleotide reduced/oxidized forms (NADH/NAD

Indexed as

AgingAlzheimer DiseaseAnimalsCell NucleusCells, CulturedCellular SenescenceCysteineCystineCytoplasmDisease Models, AnimalEnergy MetabolismFemaleHippocampusHumansIntravital MicroscopyMaleCysteineCystineNAD

Identifiers

PMID31375701
PMCPMC6677822
OpenAlexW2966246967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.