Evidence map›Paper›PMID 31375693›Full record

ArticleScientific reports2019

Rescue-like Behaviour in Mice is Mediated by Their Interest in the Restraint Tool.

Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. The Anterior Cingulate Cortex and Prosocial Behavior toward Others in Negative State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  5. Review
  6. Distinct oxytocin signaling pathways synergistically mediate rescue-like behavior in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
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  15. Article
  16. Review
  17. Article
  18. Article
  19. Body language signals for rodent social communication.Current opinion in neurobiology · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Hiroshi UenoDepartment of Medical Technology, Kawasaki University of Medical Welfare, Okayama, 701-0193, Japan. dhe422007@s.okayama-u.ac.jp.
Shunsuke SuemitsuDepartment of Psychiatry, Kawasaki Medical School, Kurashiki, 701-0192, Japan.
Shinji MurakamiDepartment of Psychiatry, Kawasaki Medical School, Kurashiki, 701-0192, Japan.ORCID http://orcid.org/0000-0001-5312-6756
Naoya KitamuraDepartment of Psychiatry, Kawasaki Medical School, Kurashiki, 701-0192, Japan.
Kenta WaniDepartment of Psychiatry, Kawasaki Medical School, Kurashiki, 701-0192, Japan.
Yu TakahashiDepartment of Psychiatry, Kawasaki Medical School, Kurashiki, 701-0192, Japan.
Yosuke MatsumotoDepartment of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, 700-8558, Japan.
Motoi OkamotoDepartment of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama, 700-8558, Japan.
Takeshi IshiharaDepartment of Psychiatry, Kawasaki Medical School, Kurashiki, 701-0192, Japan.
Kawasaki Medical School · JPOkayama University · JPKawasaki University of Medical Welfare · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acting without the expectation of compensation is called prosocial behaviour. Since prosocial behaviour requires high cognitive and social abilities, it has been thought to be only shown by primates. Although prosocial behaviour has been recently reported in rats, there are still questions regarding this finding. We demonstrated rescue-like behaviour in mice in a previous report. In this study, we investigated the motives underlying rescue-like behaviour for constrained cage-mates among mice. We prepared either a tube containing a ball of yarn or an opaque tube and assessed whether mice displayed the same rescue-like behaviour shown in the case of tube-restrained cage-mates. Mice did not open the lid of the tube containing the ball of yarn but opened the opaque tube lid. Mice showed a high interest in the tube in which the cage-mate had been restrained and prioritized staying in this tube rather than rescuing additional cage-mates. Oxytocin, which increases empathy, had no effect on the lid-opening behaviour. Thus, the rescue-like behaviour of mice is not based on empathy but is related to social interest in the cage-mate and the tube itself. These results suggest that rodent lid-opening behaviour may not conclusively prove the presence of prosocial behaviour.

Indexed as

Behavior, AnimalExploratory BehaviorSocial BehaviorAnimalsEmpathyLearningMaleMice, Inbred C57BLOxytocinPsychotropic DrugsRandom AllocationRestraint, PhysicalSpatial BehaviorOxytocinPsychotropic Drugs

Identifiers

PMID31375693
PMCPMC6677799
OpenAlexW2965240140

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.