Evidence map›Paper›PMID 31375576›Full record

ArticleJournal of virology2019

Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Acute HIV-1 Viremia.

Daniel T Claiborne, Timothy E Dudek, Colby R Maldini, Karen A Power, Musie Ghebremichael, Edward Seung, Elizabeth F Mellors, Vladimir D Vrbanac, Katharine Krupp, Abigail Bisesi and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  8. The Quest for Immunity: Exploring Human Herpesviruses as Vaccine Vectors.International journal of molecular sciences · 2023
    Review
  9. Review
  10. Review
  11. Article
  12. Humanized mouse models for immuno-oncology research.Nature reviews. Clinical oncology · 2023
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Daniel T Claiborne *Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA.
Timothy E Dudek *Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA.
Colby R MaldiniRagon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA.
Karen A PowerRagon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA.
Musie GhebremichaelRagon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA.
Edward SeungCenter for Immunology and Inflammatory Diseases, MGH, Boston, Massachusetts, USA.
Elizabeth F MellorsRagon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA.
Vladimir D VrbanacCenter for Immunology and Inflammatory Diseases, MGH, Boston, Massachusetts, USA.
Katharine KruppRagon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA.
Abigail BisesiRagon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA.
Andrew M TagerCenter for Immunology and Inflammatory Diseases, MGH, Boston, Massachusetts, USA.
David M KnipeDepartment of Microbiology and Immunology, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-1554-6236
Christian L BoutwellRagon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA.
Todd M AllenRagon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA tallen2@mgh.harvard.edu.
Ragon Institute of MGH, MIT and Harvard · USHarvard University · US

Funding

TRAINING IN HIV PATHOGENESIST32AI007632 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Frederic D Bushman, James L. Riley · 2000 to 2026
$10.6M
International Herpes Vaccine ProjectR01AI057552 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI KNIPE, DAVID M. · 2005 to 2014
$3.8M
Interrogating mechanisms of HIV pathogenesis in the humanized BLT mouse modelF32AI136750 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CLAIBORNE, DANIEL THOMAS · 2018 to 2020
$198k
International Herpes Vaccine ProjectR56AI057552 · NIAID · HARVARD MEDICAL SCHOOL · PI KNIPE, DAVID M. · 2011 to 2011
$70k
NIAID NIH HHS F32 AI136750NIAID NIH HHS R01 AI057552NIAID NIH HHS R56 AI057552NIAID NIH HHS T32 AI007632
6 · The paper itself

Abstract

BLT (bone marrow-liver-thymus) humanized mice, which reconstitute a functional human immune system, develop prototypic human virus-specific CD8

Indexed as

ViremiaAcute DiseaseAnimalsBiological EvolutionCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDisease Models, Animalgag Gene Products, Human Immunodeficiency VirusHIV-1HIV InfectionsHost-Pathogen InteractionsHumansImmunizationMiceMice, TransgenicT-Lymphocytesgag Gene Products, Human Immunodeficiency VirusCD8 T cellGagHIVhumanized micevaccine

Identifiers

PMID31375576
PMCPMC6798105
OpenAlexW2966339768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.