Evidence map›Paper›PMID 31375471›Full record

ArticleBrazilian journal of otorhinolaryngology

In vivo and in vitro study of co-expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma.

Qing Ye, Jing Li, Xiaoyan Wang, Xianzeng Zhang, Jun Lin, Yuting Huo, Zhengzhen Sun, Shusen Xie, Zheng Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Qing YeFujian Medical University, Fujian Provincial Hospital and Provincial Clinical College, Department of Otolaryngology, Fujian, China.
Jing LiFujian Medical University, Fujian Provincial Hospital and Provincial Clinical College, Department of Otolaryngology, Fujian, China. Electronic address: 417357225@qq.com.
Xiaoyan WangFujian Medical University, Fujian Provincial Hospital and Provincial Clinical College, Department of Otolaryngology, Fujian, China.
Xianzeng ZhangFujian Normal University, OptoElectronic Science and Technology for Medicine, MOE Key Laboratory, Fujian, China.
Jun LinFujian Medical University, Fujian Provincial Hospital and Provincial Clinical College, Department of Otolaryngology, Fujian, China.
Yuting HuoFujian Medical University, Fujian Provincial Hospital and Provincial Clinical College, Department of Otolaryngology, Fujian, China.
Zhengzhen SunFujian Medical University, Fujian Provincial Hospital and Provincial Clinical College, Department of Otolaryngology, Fujian, China.
Shusen XieFujian Normal University, OptoElectronic Science and Technology for Medicine, MOE Key Laboratory, Fujian, China.
Zheng HuangFujian Normal University, OptoElectronic Science and Technology for Medicine, MOE Key Laboratory, Fujian, China.
Fujian Medical University · CNFujian Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNasopharyngeal carcinoma, an epithelial-derived malignant tumor which because of its anatomical location and atypical early symptoms, when diagnosed invasion and metastasis often have occurred. This requires a better understanding of the development mechanism, identifying diagnostic markers, and developing new treatment strategies.

objectiveTo study the relationship of LMP1 and Cripto-1 in nasopharyngeal carcinoma.

methodsThe expression of LMP1 and Cripto-1 in specimens obtained from nasopharyngeal carcinoma patients (n=42) and nasopharyngitis patients (n=22) were examined. The expression of LMP1 and Cripto-1 in LMP1-negative and LMP1-positive (CNE1-LMP1) cells were also examined.

resultsThe expression of LMP1 and Cripto-1 was significantly higher in nasopharyngeal carcinoma than in nasopharyngitis (p<0.05). Their expression in nasopharyngeal carcinoma with metastasis were significantly higher than that without metastasis (p<0.05), which was correlated with TNM staging (p<0.05). High Cripto-1 expression and high proliferation rate were seen in CNE1-LMP1 cells.

conclusionsThe expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma is positively related. Their co-expression might contribute to the proliferation and metastasis of nasopharyngeal carcinoma.

Indexed as

Nasopharyngeal CarcinomaNasopharyngeal NeoplasmsBacterial Outer Membrane ProteinsHumansIntercellular Signaling Peptides and ProteinsViral Matrix ProteinsBacterial Outer Membrane ProteinsIntercellular Signaling Peptides and ProteinsLmp1 antigen, MycoplasmaViral Matrix ProteinsCarcinoma nasofaríngeoCripto-1LMP1MetástaseMetastasisNasopharyngeal carcinoma

Identifiers

PMID31375471
PMCPMC9422379
OpenAlexW2946410886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.