ArticleJournal of geriatric oncology2020
Barriers to clinical trial enrollment of older adults with cancer: A qualitative study of the perceptions of community and academic oncologists.
Article in Journal of geriatric oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Applying the Bradford Hill Criteria to Assess the Independent Causal Roles of Aging and Medication in Frailty Progression: A Systematic Review.Drugs & aging · 2026Pooled it
- Older adult participation in cancer clinical trials: A systematic review of barriers and interventions.CA: a cancer journal for clinicians · 2021Pooled it
- A stratified adaptive two-stage design with co-primary endpoints for phase II clinical oncology trials.BMC medical research methodology · 2022Trial
- Geographic access to triple negative breast cancer clinical trials: are trials located near patients?Breast cancer research and treatment · 2026Article
- Evaluation of the Japanese National clinical database risk calculator as a surrogate frailty assessment tool for older adults with colorectal cancer.Surgery today · 2026Article
- Closing the gap of older adult recruitment to cancer clinical trials: a scoping review.BMC cancer · 2026Article
- Lung cancer treatment pathways in the largest private health insurance in Brazil: a real-world data study.BMC cancer · 2026Article
- The ESMO/SIOG Cancer in the Elderly Working Group pragmatic strategies for clinical trial designs and endpoints in older adults with cancer.ESMO open · 2026Review
- Increasing Diversity in Head and Neck Cancer Clinical Trials.Current treatment options in oncology · 2026Review
- Current Evidence and Intervention Approaches for Physical Activity and Low Back Pain in Older Adult Populations: A Narrative Review.BioMed research international · 2026Review
- Impact of Age and Comorbidities On Therapeutic Decision-making Among Older Patients With Gastrointestinal Cancer.Journal of gastrointestinal cancer · 2025Article
- Article
- Stakeholder perspectives on the role of caregivers in cancer clinical trial decision-making: results of a qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Optimizing Transitions of Care in Multiple Myeloma Immunotherapy: Nurse Roles.Clinical journal of oncology nursing · 2025Article
- COVID-19 clinical trial participation and awareness in Texas.Human vaccines & immunotherapeutics · 2024Article
- National Institute on Aging efforts toward ensuring representation of diverse older adults in clinical studies.Journal of the American Geriatrics Society · 2024Article
- Clinical trials in older patients with cancer - typical challenges, possible solutions, and a paradigm of study design in breast cancer.Acta oncologica (Stockholm, Sweden) · 2024Review
- Development and Evaluation of a Multisource Approach to Extend Mortality Follow-Up for Older Adults With Advanced Cancer Enrolled in Randomized Trials.JCO clinical cancer informatics · 2024Article
- Real-World Experience of Immune-Checkpoint Inhibitors in Older Patients with Advanced Cutaneous Squamous Cell Carcinoma.Drugs & aging · 2024Article
- Disentangling the reasons why older adults do not readily participate in cancer trials: a socio-epidemiological mixed methods approach.Age and ageing · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesOncologists can be one of the major barriers to older adult's participation in research. Multiple studies have described academic clinicians' concerns for not enrolling older adults onto trials. Although the majority of older adults receive their cancer care in the community, few studies have examined the unique challenges that community oncologists face and how they differ from oncologist-related barriers in academia.
methodsSemi-structured interviews were conducted by telephone or face-to-face with 44 medical oncologists (24 academic-based and 20 community-based) at City of Hope from March to June 2018. Interviews explored oncologists' perceptions of barriers to clinical trial enrollment of older adults with cancer. Data were analyzed using qualitative content analysis.
resultsOf the 44 participants, 36% were women and 68% were in practice for >10 years. Among the entire sample, stringent eligibility criteria (n = 20) and oncologist concerns for treatment toxicities (n = 15) were the most commonly cited barriers. Compared to academic oncologists, community oncologists more often cited patient attitudes, beliefs, and understanding (n = 9 vs. n = 2) and caregiver burden (n = 6 vs. n = 0). In contrast, compared to community oncologists, academic oncologists more often cited oncologist bias (n = 10 vs. n = 3) and insufficient time/support (n = 4 vs. n = 1).
conclusionsDifferences in perceptions among academic and community oncologists about trials suggest that barriers are multifaceted, complex, and vary by practice setting. Interventions to increase trial accrual among older adults with cancer may benefit from being tailored to address the unique barriers of different practice settings.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.