Evidence map›Paper›PMID 31375207›Full record

ReviewSleep medicine clinics2019

Precision Medicine for Obstructive Sleep Apnea.

Matthew Light, Robert L Owens, Christopher N Schmickl, Atul Malhotra

Open access · greenAbstract readReview
In one paragraph

Review in Sleep medicine clinics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 43 citations in OpenAlex.

  1. The effects of mandibular advancement appliance therapy on jaw-closing muscle activity during sleep in patients with obstructive sleep apnea: a 3-6 months follow-up.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020
    Trial
  2. Trial
  3. Review
  4. Validation of a deep learning-based system for sleep staging, arousal detection, and respiratory event scoring in atrial fibrillation patients.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Computed Tomography and Cephalometric Evaluation of Obstructive Sleep Apnea Syndrome.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Matthew LightDivision of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, 9300 Campus Point Drive #7381, La Jolla, CA 92037-7381, USA. Electronic address: mlight@ucsd.edu.
Robert L OwensDivision of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, 9300 Campus Point Drive #7381, La Jolla, CA 92037-7381, USA.
Christopher N SchmicklDivision of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, 9300 Campus Point Drive #7381, La Jolla, CA 92037-7381, USA.
Atul MalhotraDivision of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, 9300 Campus Point Drive #7381, La Jolla, CA 92037-7381, USA.
University of California, San Diego · USUniversity of California System · US

Funding

Single Motor Unit Genioglossus Recordings to Understand Sleep Apnea PathogenesisR01HL085188 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2008 to 2018
$3.5M
Training in the Next Generation in Respiratory ScienceT32HL134632 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, POWELL, FRANK L. · 2017 to 2021
$2.1M
Assessment of Upper Airway Mechanics Using Newer Electromyographic TechniquesK24HL132105 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2016 to 2020
$611k
NHLBI NIH HHS K24 HL132105NHLBI NIH HHS R01 HL085188NHLBI NIH HHS T32 HL134632
6 · The paper itself

Abstract

Increasingly, obstructive sleep apnea treatment is being recognized as amenable to a precision medicine approach. Many pathophysiologic mechanisms (endotypes) beyond anatomic compromise have now been identified and are readily determined during polysomnography, although randomized controlled trials of endotype-specific therapies are needed. Research indicates that endotypes may also be important in predicting both adherence to therapy and disease consequences (phenotypes). Biomarker discovery and Big Data approaches derived from wearable technology are areas of active investigation and may allow more robust conclusions to be drawn over time, such that patients may soon fully realize the benefits from fresh insights into sleep science.

Indexed as

Precision MedicineContinuous Positive Airway PressureEndophenotypesHumansPolysomnographySleepSleep Apnea, ObstructiveArousal thresholdLoop gainObstructive sleep apneaOSA TreatmentPrecision medicine

Identifiers

PMID31375207
PMCPMC8931687
OpenAlexW2954605012

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.