Evidence map›Paper›PMID 31375003›Full record

ArticleMolecules (Basel, Switzerland)2019

Antibacterial Activity and Molecular Docking Studies of a Selected Series of Hydroxy-3-arylcoumarins.

Maria Barbara Pisano, Amit Kumar, Rosaria Medda, Gianluca Gatto, Rajesh Pal, Antonella Fais, Benedetta Era, Sofia Cosentino, Eugenio Uriarte, Lourdes Santana and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 120 citations in OpenAlex.

  1. Hexane extract ofRSC advances · 2026
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  8. Frontiers in bioinformatics · 2025
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  18. Design, synthetic approach,RSC advances · 2022
    Article
  19. Natural source, bioactivity and synthesis of 3-Arylcoumarin derivatives.Journal of enzyme inhibition and medicinal chemistry · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 3 countries.

Maria Barbara PisanoDepartment of Medical Sciences and Public Health, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy.
Amit KumarDepartment of Electrical and Electronic Engineering, University of Cagliari, Via Marengo 2, 09123 Cagliari, Italy.
Rosaria MeddaDepartment of Sciences of Life and Environment, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy.
Gianluca GattoDepartment of Electrical and Electronic Engineering, University of Cagliari, Via Marengo 2, 09123 Cagliari, Italy.
Rajesh PalDepartment of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy.
Antonella FaisDepartment of Sciences of Life and Environment, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy. fais@unica.it.
Benedetta EraDepartment of Sciences of Life and Environment, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy. era@unica.it.
Sofia CosentinoDepartment of Medical Sciences and Public Health, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy.
Eugenio UriarteDepartment of Organic Chemistry, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Lourdes SantanaDepartment of Organic Chemistry, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Francesca PintusDepartment of Sciences of Life and Environment, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy.
Maria João MatosDepartment of Organic Chemistry, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.
University of Cagliari · ITUniversidade de Santiago de Compostela · ES

Funding

Università degli Studi di Cagliari FIRXunta da Galicia Plan I2C ED481B 2014/086-0Xunta da Galicia Plan I2C ED481B 2018/007
6 · The paper itself

Abstract

Antibiotic resistance is one of the main public health concerns of this century. This resistance is also associated with oxidative stress, which could contribute to the selection of resistant bacterial strains. Bearing this in mind, and considering that flavonoid compounds are well known for displaying both activities, we investigated a series of hydroxy-3-arylcoumarins with structural features of flavonoids for their antibacterial activity against different bacterial strains. Active compounds showed selectivity against the studied Gram-positive bacteria compared to Gram-negative bacteria. 5,7-Dihydroxy-3-phenylcoumarin (compound

Indexed as

Structure-Activity RelationshipAnti-Bacterial AgentsBacillus cereusBacterial InfectionsCoumarinsDNA GyraseHumansListeria monocytogenesMolecular Docking SimulationStaphylococcus aureusAnti-Bacterial AgentsCoumarinsDNA Gyraseantibacterial activityhydroxy-3-arylcoumarinsmolecular dockingPerkin–Oglialoro reaction

Identifiers

PMID31375003
PMCPMC6696357
OpenAlexW2964458079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.