Evidence map›Paper›PMID 31374989›Full record

ArticleMolecules (Basel, Switzerland)2019

Primaquine and Chloroquine Fumardiamides as Promising Antiplasmodial Agents.

Maja Beus, Diana Fontinha, Jana Held, Zrinka Rajić, Lidija Uzelac, Marijeta Kralj, Miguel Prudêncio, Branka Zorc

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Batch Synthesis of Primaquine Diphosphate Anti-Malarial Drug.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  2. Article
  3. Review
  4. Primaquine derivatives: Modifications of the terminal amino group.European journal of medicinal chemistry · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Maja BeusUniversity of Zagreb, Faculty of Pharmacy and Biochemistry, A. Kovačića 1, HR-10 000 Zagreb, Croatia.
Diana FontinhaInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisboa, Portugal.
Jana HeldUniversity of Tübingen, Institute of Tropical Medicine, Wilhelmstraße 27, 72074 Tübingen, Germany.
Zrinka RajićUniversity of Zagreb, Faculty of Pharmacy and Biochemistry, A. Kovačića 1, HR-10 000 Zagreb, Croatia. zrajic@pharma.hr.
Lidija UzelacRudjer Bošković Institute, Division of Molecular Medicine, Laboratory of Experimental Therapy, 10 000 Zagreb, Croatia.
Marijeta KraljRudjer Bošković Institute, Division of Molecular Medicine, Laboratory of Experimental Therapy, 10 000 Zagreb, Croatia.
Miguel PrudêncioInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisboa, Portugal.
Branka ZorcUniversity of Zagreb, Faculty of Pharmacy and Biochemistry, A. Kovačića 1, HR-10 000 Zagreb, Croatia. bzorc@pharma.hr.
University of Zagreb · HRRuđer Bošković Institute · HRUniversity of Lisbon · PTUniversity of Tübingen · DE

Funding

Fundação para a Ciência e Tecnologia Stimulus of Scientific Employement 2018Hrvatska Zaklada za Znanost IP-2014-09-1501, IP-2013-5660Hrvatska Zaklada za Znanost Young researcher's career development project - training of doctoral studentsUniversity of Zagreb support for 2018
6 · The paper itself

Abstract

This paper describes a continuation of our efforts in the pursuit of novel antiplasmodial agents with optimized properties. Following our previous discovery of biologically potent asymmetric primaquine (PQ) and halogenaniline fumardiamides (

Indexed as

AntimalarialsChloroquineErythrocytesHEK293 CellsHumansMalaria, FalciparumMolecular StructurePlasmodium falciparumPrimaquineStructure-Activity RelationshipAntimalarialsChloroquinePrimaquineantiplasmodial activitychloroquinecytotoxicityfumardiamideprimaquine

Identifiers

PMID31374989
PMCPMC6695747
OpenAlexW2965175176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.