Evidence map›Paper›PMID 31374890›Full record

ArticleMolecules (Basel, Switzerland)2019

Estimating the Solubility, Solution Thermodynamics, and Molecular Interaction of Aliskiren Hemifumarate in Alkylimidazolium Based Ionic Liquids.

Md Khalid Anwer, Mohammad Muqtader, Muzaffar Iqbal, Raisuddin Ali, Bjad K Almutairy, Abdullah Alshetaili, Saad M Alshahrani, Mohammed F Aldawsari, Ahmed Alalaiwe, Faiyaz Shakeel

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Md Khalid AnwerDepartment of Pharmaceutics, College of Pharmacy Prince Sattam Bin Abdulaziz University, Al-Alkharj, 11942, Saudi Arabia. mkanwer2002@yahoo.co.in.
Mohammad MuqtaderDepartment of Pharmaceutics, College of Pharmacy Prince Sattam Bin Abdulaziz University, Al-Alkharj, 11942, Saudi Arabia.
Muzaffar IqbalDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Raisuddin AliDepartment of Pharmaceutics and Central Lab, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Bjad K AlmutairyDepartment of Pharmaceutics, College of Pharmacy Prince Sattam Bin Abdulaziz University, Al-Alkharj, 11942, Saudi Arabia.
Abdullah AlshetailiDepartment of Pharmaceutics, College of Pharmacy Prince Sattam Bin Abdulaziz University, Al-Alkharj, 11942, Saudi Arabia.
Saad M AlshahraniDepartment of Pharmaceutics, College of Pharmacy Prince Sattam Bin Abdulaziz University, Al-Alkharj, 11942, Saudi Arabia.
Mohammed F AldawsariDepartment of Pharmaceutics, College of Pharmacy Prince Sattam Bin Abdulaziz University, Al-Alkharj, 11942, Saudi Arabia.ORCID 0000-0003-1298-4863
Ahmed AlalaiweDepartment of Pharmaceutics, College of Pharmacy Prince Sattam Bin Abdulaziz University, Al-Alkharj, 11942, Saudi Arabia.
Faiyaz ShakeelDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

Funding

Deanship of Scientific Research at Prince Sattam Bin Abdulaziz University 2019/03/10912
6 · The paper itself

Abstract

Estimating the solubility and solution thermodynamics parameters of aliskiren hemifumarate (AHF) in three different room temperature ionic liquids (RTILs), Transcutol-HP (THP) and water are interesting as there is no solubility data available in the literature. In the current study, the solubility and solution thermodynamics of AHF in three different RTILs, THP and water at the temperature range from 298.2 to 318.2 K under air pressure 0.1 MP were evaluated. The solid phase evaluation by Differential Scanning Calorimetry (DSC) and Powder X-ray Diffraction (PXRD) indicated no conversion of AHF into polymorph. The mole fraction solubility of AHF was found to be highest in 1-hexyl-3-methylimidazolium hexafluorophosphate (HMMHFP) ionic liquid (7.46 × 10

Indexed as

ThermodynamicsAmidesEthylene GlycolsFumaratesIonic LiquidsSolubilitySolventsTemperatureWaterX-Ray DiffractionaliskirenAmidescarbitolEthylene GlycolsFumaratesIonic LiquidsSolventsWaterentropyionic liquidsmolecular interactionsolubilitythermodynamics

Identifiers

PMID31374890
PMCPMC6695967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.