ReviewDentistry journal2019
A Critical Review of Modern Concepts for Teeth Whitening.
Review in Dentistry journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04460755 (Tooth Whitening Evaluation With Cytotoxic and Genotoxic Effect of Commercial Whitening Toothpastes on Oral Mucosal Cells), which is not on this map. Cited by 70 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Tooth Whitening Evaluation With Cytotoxic and Genotoxic Effect of Commercial Whitening Toothpastes on Oral Mucosal Cells
Who cites it
70 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Blue Covarine in Toothpaste: A Comprehensive Review and Meta Analysis of Efficacy, Safety, and Potential Effects.International journal of dental hygiene · 2026Pooled it
- Effect of whitening toothpaste on surface roughness and microhardness of human teeth: a systematic review and meta-analysis.F1000Research · 2022Pooled it
- Comparative evaluation of LED- and diode laser-assisted in-office tooth whitening: a pilot randomized clinical study.BMC oral health · 2026Trial
- Bleaching with biocatalysts and violet LED: a randomized clinical trial using a hybrid design with parallel-group and split-mouth approaches : Violet LED and biocatalysts in in-office whitening: a split-mouth trial.Clinical oral investigations · 2025Trial
- In vivo evaluation of whitening toothpaste efficiency and patient treatment satisfaction: a randomized controlled trial.Clinical oral investigations · 2022Trial
- Reduction of extrinsic tooth stain by a toothpaste containing 10% high cleaning silica, 0.5% sodium phytate and 0.5% sodium pyrophosphate: an 8-week randomised clinical trial.BMC oral health · 2021Trial
- Whitening Effect of Different Toothpastes on Bovine Dental Enamel: an in situ study.Brazilian dental journalTrial
- The effects of hydrogen peroxide on the proliferation ability and odontogenic differentiation ability of hDPCs.BMC oral health · 2026Article
- Surface roughness changes in bulk-fill resin composites after simulated toothbrushing with whitening toothpastes.BMC oral health · 2026Article
- Effect Of Arginine And Spray-Dried Chitosan Pretreatment On Microshear Bond Strength To Bleached Enamel.Clinical, cosmetic and investigational dentistry · 2026Article
- Tooth-Specific Personalization of In-Office Whitening Time: A Three-Case Report.Case reports in dentistry · 2026Article
- Knowledge, Attitudes, and Practices Regarding Over-the-Counter Teeth Whitening Products Among Adults in Saudi Arabia: A Cross-Sectional Survey.Clinical, cosmetic and investigational dentistry · 2026Article
- Shades of knowledge: awareness among Brazilian dentists on non- and microinvasive approaches for tooth discoloration.Journal of applied oral science : revista FOB · 2026Observational
- Zirconium particles in toothpaste: a novel approach to whitening and its impact on enamel wear.BMC oral health · 2025Article
- Innovations in teeth bleaching: harnessing antimicrobial photodynamic therapy for enhanced outcomes.Lasers in medical science · 2025Review
- Evaluation of Tooth Color Changes at Different Concentrations of Zirconia Toothpaste: A Pilot In Vitro Study.Dentistry journal · 2025Article
- Hydrogen Peroxide-Free Color Correctors for Tooth Whitening in Adolescents and Young Adults: A Systematic Review of In Vitro and Clinical Evidence.Dentistry journal · 2025Review
- Effects of different charcoal-containing whitening toothpastes on color and surface roughness of a supra-nanofilled composite resin.BMC oral health · 2025Article
- Charcoal whitening agents and composite resin: investigating color change and surface roughness.BMC oral health · 2025Article
- From Microstructure to Shade Shift: Confocal and Spectrophotometric Evaluation of Peroxide-Induced Dental Bleaching.Journal of clinical medicine · 2025Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Besides prevention of caries and periodontitis, an increasing number of oral care products focus on teeth whitening. The aim of this review is to summarize and discuss frequently used whitening agents and their efficacy from a chemical viewpoint. Therefore, a comprehensive literature survey on teeth whitening agents and products was conducted. The current whitening methods are analyzed and discussed from a chemist's viewpoint. Frequently used whitening agents are abrasives (mechanical removal of stains), antiredeposition agents (prevention of deposition of chromophores), colorants (intended to lead to a white color), proteases (degradation of proteins), peroxides (oxidation of organic chromophores), and surfactants (removal of hydrophobic compounds from tooth surface). In-office bleaching using peroxides is effective, but side effects like tooth sensitivity or a damage of the natural organic matrix of enamel and dentin may occur. The applicability of abrasives in teeth whitening is limited due to potential tooth wear, especially when toothpastes with high RDA values are used. The effect of other whitening agents in vivo is often unclear because of a shortage of placebo-controlled clinical trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.