Trial reportThe American journal of clinical nutrition2019
True ileal digestibility of legumes determined by dual-isotope tracer method in Indian adults.
Trial report in The American journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 69 citations in OpenAlex.
- Complementary plant protein pairing does not further increase postexercise myofibrillar protein synthesis after a 20 g protein dose within a high-carbohydrate whole-food matrix in young adults: a randomized controlled trial.The American journal of clinical nutrition · 2026Trial
- Differences in amino acid digestibility between young and older adults: a randomized crossover study using the dual tracer method.The American journal of clinical nutrition · 2026Trial
- Ingestion of 20 g Whey or Canola Protein Does Not Further Increase Muscle Protein Synthesis Rates During Recovery From Resistance Exercise In Healthy, Young Females.The Journal of nutrition · 2025Trial
- Investigating the Digestibility, Bioavailability and Utilization of Protein Blends in Older Adults Using a Dual Stable Isotope Tracer Technique.Nutrients · 2025Trial
- Evaluation of processing of canola protein isolate on postprandial plasma amino acid profiles in healthy, young females.Amino acids · 2025Trial
- Postprandial plasma aminoacidemia and indices of appetite regulation following pea-rice blend, pea isolate and whey protein ingestion in healthy young adults.The British journal of nutrition · 2024Trial
- True Ileal Amino Acid Digestibility and Protein Quality ofThe Journal of nutrition · 2024Trial
- Post-prandial muscle protein synthesis rates following the ingestion of pea-derived protein do not differ from ingesting an equivalent amount of milk-derived protein in healthy, young males.European journal of nutrition · 2024Trial
- The Muscle Protein Synthetic Response to the Ingestion of a Plant-Derived Protein Blend Does Not Differ from an Equivalent Amount of Milk Protein in Healthy Young Males.The Journal of nutrition · 2023Trial
- Blood 15N:13C Enrichment Ratios Are Proportional to the Ingested Quantity of Protein with the Dual-Tracer Approach for Determining Amino Acid Bioavailability in Humans.The Journal of nutrition · 2020Trial
- Amino Acid Digestibility of Extruded Chickpea and Yellow Pea Protein is High and Comparable in Moderately Stunted South Indian Children with Use of a Dual Stable Isotope Tracer Method.The Journal of nutrition · 2020Trial
- The fate of dietary protein in the gastrointestinal tract and implications for colonic disease.Nature reviews. Gastroenterology & hepatology · 2026Review
- Dietary Protein Intake in CKD: Quantity and Quality.Clinical journal of the American Society of Nephrology : CJASN · 2026Review
- Understanding Dietary Protein Quality: Digestible Indispensable Amino Acid Scores and Beyond.The Journal of nutrition · 2025Review
- Influence of Nitrogen Fertilization and Cutting Dynamics on the Yield and Nutritional Composition of White Clover (Plants (Basel, Switzerland) · 2025Article
- How stable isotopes can advance nutrition assessments to inform sustainable food systems.The British journal of nutrition · 2025Review
- Metabolic pathways mediating insulin resistance and gestational diabetes mellitus discovered by high-dimensional systematic Mendelian randomization.Cardiovascular diabetology · 2025Article
- Identifying the optimal ratio from protein foods for protein and nutrient quality in plant-based meals using a non-linear optimization approach.Frontiers in nutrition · 2025Article
- Potential of edible insects as alternative protein source for the older adults.Current research in food science · 2025Review
- Secondary Bioactive Metabolites from Foods of Plant Origin asFoods (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundGood-quality plant protein sources are important for protein adequacy in a balanced diet. Legumes are known to be a source of good quality plant protein, but the true ileal digestibility of indispensable amino acids (IAAs) of commonly consumed legumes is not known in humans.
objectivesIn this study we measured the true ileal IAA digestibility of 2H-intrinsically labeled chickpea, yellow pea, and mung bean (hulled and dehulled) protein, using the dual-isotope tracer technique referenced to a standard protein ([U-13C] spirulina). The study also aimed to validate the use of [U-13C] spirulina as a reference protein in this method.
methods2H-intrinsically labeled legumes, obtained by watering plants with deuterium oxide (2H2O), were administered in a plateau feeding method to healthy Indian adults to measure their true ileal IAA digestibility with the dual-isotope tracer technique, using [U-13C] spirulina protein or a 13C-algal IAA mixture as the standard.
resultThe true ileal IAA digestibilities (mean ± SD) of chickpea, yellow pea, and mung bean were 74.6 ± 0.8%, 71.6 ± 1.3%, and 63.2 ± 1.5%, respectively. The true mean ileal IAA digestibility of mung bean when referenced to [U-13C] spirulina protein or a 13C-algal IAA mixture did not differ significantly (63.2 ± 1.5% versus 64.0 ± 2.4%, P > 0.05). The true ileal IAA digestibility of mung bean improved to 70.9 ± 2.1% after dehulling.
conclusionsThe true mean ileal IAA digestibility of legumes in healthy Indian adults was lower than expected. Traditional processing techniques such as dehulling improve protein digestibility by about 8%. This study was registered in the Clinical Trials Registry of India (CTRI): CTRI/2017/11/010468 (http://ctri.nic.in, accessed on 28/03/2019).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.