Evidence map›Paper›PMID 31374195›Full record

ArticleCell stem cell2019

Calcium: A New Guardian of Naive Pluripotency.

Yuqing Zhu, Jin Zhang

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell stem cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. ATP2B1 expression identifies human hematopoietic stem cells with superior repopulation and self-renewal.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Yuqing ZhuCenter for Stem Cell and Regenerative Medicine, Department of Basic Medical Sciences & Zhejiang University-University of Edinburgh Joint Institute, Zhejiang University School of Medicine, Hangzhou 310058, China.
Jin ZhangCenter for Stem Cell and Regenerative Medicine, Department of Basic Medical Sciences & The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address: zhgene@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this issue of Cell Stem Cell, MacDougall et al. (2019) utilized a CRISPR mutagenesis screen to identify factors for mESC self-renewal and found that intracellular calcium and nuclear export act in naive pluripotency exit. Combined knockout of Tcf7l1 and the calcium transporter Atp2b1 enabled mESCs to self-renew in the absence of LIF and 2i.

Indexed as

CalciumMouse Embryonic Stem CellsActive Transport, Cell NucleusCytoplasmHomeostasisCalcium

Identifiers

PMID31374195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.