ArticleJournal of biomechanical engineering2019
Anisotropic Material Characterization of Human Cervix Tissue Based on Indentation and Inverse Finite Element Analysis.
Article in Journal of biomechanical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Towards deep phenotyping pregnancy: a systematic review on artificial intelligence and machine learning methods to improve pregnancy outcomes.Briefings in bioinformatics · 2021Pooled it
- A finite element model of pregnancy derived from maternal sonography: effect of uterine and cervical structural properties on cervical mechanical loading.bioRxiv : the preprint server for biology · 2026Article
- Microstructure-Informed Hyper-Viscoelastic Model Capturing Soft Tissue Tensile Behavior Across Large Deformations.Journal of the mechanics and physics of solids · 2026Article
- Equilibrium mechanical properties of the human uterus in tension and compression.Acta biomaterialia · 2025Article
- Finite element modeling in obstetrics and gynecology: advances, applications, and challenges.Frontiers in medicine · 2025Review
- Quantitative Assessment of Collagen Remodeling during a Murine Pregnancy.ACS photonics · 2024Article
- Equilibrium Mechanical Properties of the Nonhuman Primate Cervix.Journal of biomechanical engineering · 2024Article
- Equilibrium Tension and Compression Mechanical Properties of the Human Uterus.bioRxiv : the preprint server for biology · 2024Article
- Elasticity of the Cervix in Relation to Uterus Position.Journal of clinical medicine · 2024Article
- A finite porous-viscoelastic model capturing mechanical behavior of human cervix under multi-step spherical indentation.Journal of the mechanical behavior of biomedical materials · 2023Article
- Can machine learning accelerate soft material parameter identification from complex mechanical test data?Biomechanics and modeling in mechanobiology · 2023Article
- Bioengineering and the cervix: The past, current, and future for addressing preterm birth.Current research in physiology · 2023Review
- Three-dimensional anisotropic hyperelastic constitutive model describing the mechanical response of human and mouse cervix.Acta biomaterialia · 2022Article
- Mechanical Response of Mouse Cervices Lacking Decorin and Biglycan During Pregnancy.Journal of biomechanical engineering · 2022Article
- Measuring mechanical anisotropy of the cornea with Brillouin microscopy.Nature communications · 2022Article
- Anisotropic Mechanical Properties of the Human Uterus Measured by Spherical Indentation.Annals of biomedical engineering · 2021Article
- 3D Finite Element Modeling of Blast Wave Transmission from the External Ear to Cochlea.Annals of biomedical engineering · 2021Article
- An optomechanogram for assessment of the structural and mechanical properties of tissues.Scientific reports · 2021Article
- Hyperelastic Ex Vivo Cervical Tissue Mechanical Characterization.Sensors (Basel, Switzerland) · 2020Article
- Why Are Viscosity and Nonlinearity Bound to Make an Impact in Clinical Elastographic Diagnosis?Sensors (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The cervix is essential to a healthy pregnancy as it must bear the increasing load caused by the growing fetus. Preterm birth is suspected to be caused by the premature softening and mechanical failure of the cervix. The objective of this paper is to measure the anisotropic mechanical properties of human cervical tissue using indentation and video extensometry. The human cervix is a layered structure, where its thick stromal core contains preferentially aligned collagen fibers embedded in a soft ground substance. The fiber composite nature of the tissue provides resistance to the complex three-dimensional loading environment of pregnancy. In this work, we detail an indentation mechanical test to obtain the force and deformation response during loading which closely matches in vivo conditions. We postulate a constitutive material model to describe the equilibrium material behavior to ramp-hold indentation, and we use an inverse finite element method based on genetic algorithm (GA) optimization to determine best-fit material parameters. We report the material properties of human cervical slices taken at different anatomical locations from women of different obstetric backgrounds. In this cohort of patients, the anterior internal os (the area where the cervix meets the uterus) of the cervix is stiffer than the anterior external os (the area closest to the vagina). The anatomic anterior and posterior quadrants of cervical tissue are more anisotropic than the left and right quadrants. There is no significant difference in material properties between samples of different parities (number of pregnancies reaching viable gestation age).
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Registered trials
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