ArticleSleep2019
Evidence for sleep-dependent synaptic renormalization in mouse pups.
Article in Sleep, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Synaptic Mitochondrial Oxidative Stress Contributes to Individual Variability in Age-Related Cognitive Inflexibility in Mice.Aging cell · 2026Article
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- Latent mechanisms of plasticity are upregulated during sleep.Current opinion in neurobiology · 2025Review
- Excitatory/Inhibitory imbalance as a mechanism linking autism and sleep problems.Current opinion in neurobiology · 2025Review
- Article
- Developmental alcohol exposure is exhausting: Sleep and the enduring consequences of alcohol exposure during development.Neuroscience and biobehavioral reviews · 2024Review
- Loss of sleep when it is needed most - Consequences of persistent developmental sleep disruption: A scoping review of rodent models.Neurobiology of sleep and circadian rhythms · 2023Article
- Regulation of dendritic spines in the amygdala following sleep deprivation.Frontiers in sleep · 2023Article
- Adolescent sleep and the foundations of prefrontal cortical development and dysfunction.Progress in neurobiology · 2022Review
- The why and how of sleep-dependent synaptic down-selection.Seminars in cell & developmental biology · 2022Article
- Stability of neocortical synapses across sleep and wake states during the critical period in rats.eLife · 2021Article
- Article
- Molecular Mechanisms of Memory Consolidation That Operate During Sleep.Frontiers in molecular neuroscience · 2021Review
- Roles for Sleep in Neural and Behavioral Plasticity: Reviewing Variation in the Consequences of Sleep Loss.Frontiers in behavioral neuroscience · 2021Review
- The Ontogenesis of Mammalian Sleep: Form and Function.Current sleep medicine reports · 2020Article
- Sleep, brain vascular health and ageing.GeroScience · 2020Review
- Structural synaptic plasticity across sleep and wake.Current opinion in physiology · 2020Review
- Impacts of Sleep Loss versus Waking Experience on Brain Plasticity: Parallel or Orthogonal?Trends in neurosciences · 2020Review
- Effects of sleep and waking on the synaptic ultrastructure.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Article
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Authors and funding
11 authors.
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Abstract
In adolescent and adult brains several molecular, electrophysiological, and ultrastructural measures of synaptic strength are higher after wake than after sleep [1, 2]. These results support the proposal that a core function of sleep is to renormalize the increase in synaptic strength associated with ongoing learning during wake, to reestablish cellular homeostasis and avoid runaway potentiation, synaptic saturation, and memory interference [2, 3]. Before adolescence however, when the brain is still growing and many new synapses are forming, sleep is widely believed to promote synapse formation and growth. To assess the role of sleep on synapses early in life, we studied 2-week-old mouse pups (both sexes) whose brain is still undergoing significant developmental changes, but in which sleep and wake are easy to recognize. In two strains (CD-1, YFP-H) we found that pups spend ~50% of the day asleep and show an immediate increase in total sleep duration after a few hours of enforced wake, indicative of sleep homeostasis. In YFP-H pups we then used serial block-face electron microscopy to examine whether the axon-spine interface (ASI), an ultrastructural marker of synaptic strength, changes between wake and sleep. We found that the ASI of cortical synapses (layer 2, motor cortex) was on average 33.9% smaller after sleep relative to after extended wake and the differences between conditions were consistent with multiplicative scaling. Thus, the need for sleep-dependent synaptic renormalization may apply also to the young, pre-weaned cerebral cortex, at least in the superficial layers of the primary motor area.
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