Evidence map›Paper›PMID 31374107›Full record

ArticlePloS one2019

Failures in the case management of children with uncomplicated malaria in Bata district of Equatorial Guinea and associated factors.

Pablo Suárez-Sánchez, Belén García, Jesús Nzang, Policarpo Ncogo, Matilde Riloha, Pedro Berzosa, Agustín Benito, María Romay-Barja

Abstract read
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pablo Suárez-SánchezCentro Nacional de Medicina Tropical, Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0001-7617-6799
Belén GarcíaCentro Nacional de Medicina Tropical, Instituto de Salud Carlos III, Madrid, Spain.
Jesús NzangCentro de Referencia de Control de Endemias, Malabo, Equatorial Guinea.
Policarpo NcogoCentro de Referencia de Control de Endemias, Malabo, Equatorial Guinea.
Matilde RilohaMinisterio de Salud y Bienestar Social, Malabo, Equatorial Guinea.
Pedro BerzosaCentro Nacional de Medicina Tropical, Instituto de Salud Carlos III, Madrid, Spain.
Agustín BenitoCentro Nacional de Medicina Tropical, Instituto de Salud Carlos III, Madrid, Spain.
María Romay-BarjaCentro Nacional de Medicina Tropical, Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0002-0177-6885

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn Equatorial Guinea, malaria continues to be one of the main causes of morbidity and mortality among children. The National Therapeutic Guide established artesunate-amodiaquine (ASAQ) as first-line treatment for uncomplicated malaria, but compliance with this treatment is low. The aim of this study was to assess, for the first time, the performance of public healthcare workers in the diagnosis and treatment of uncomplicated malaria, their compliance with first-line Malaria National Therapeutic Guide and the associated factors.

methodsA cross-sectional survey was conducted at the nine public health facilities in the Bata District of Equatorial Guinea to assess the management of uncomplicated malaria in children < 15 years of age. Bivariate and multivariate statistical analyses were used to determine the recommended treatment compliance and related factors.

resultsA total of 227 children with uncomplicated malaria were recorded from 9 public health facilities. Most of the treatments prescribed (83.3%) did not follow the first-line treatment recommended for uncomplicated malaria. The diagnosis was established with parasite confirmation in 182 cases (80.2%). After adjustment for other variables, children under 2 months of age, the use of parasite confirmation to the diagnosis of malaria and being familiar with the national therapeutic guide were significantly associated with the prescription of the first-line recommended treatment. Cases attended at the hospital or in a health facility with ASAQ in the pharmacy at the time of the study were also more likely to be prescribed with the recommended treatment, but with non-significant association after adjustment for other variables.

conclusionsThis study identified the factors associated with the low compliance with the first-line treatment by the public healthcare facilities of Bata District of Equatorial Guinea. It seems necessary to improve case management of children with uncomplicated malaria; to reinforce the use of Malaria National Therapeutic Guide and to inform about the danger of using artemisinin monotherapy. Furthermore, it is crucial to provide recommended first-line treatment to the pharmacies of all public health facilities to ensure access to this treatment.

Indexed as

AdolescentAmodiaquineAntimalarialsArtemisininsCase ManagementChildChild, PreschoolCross-Sectional StudiesDrug CombinationsEquatorial GuineaGuideline AdherenceHealth Care SurveysHealth FacilitiesHumansInfantInfant, NewbornAmodiaquineamodiaquine, artesunate drug combinationAntimalarialsArtemisininsDrug Combinations

Identifiers

PMID31374107
PMCPMC6677319

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.