ArticlePloS one2019
Adverse obstetrical outcomes for women with endometriosis and adenomyosis: A large cohort of the Japan Environment and Children's Study.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04894292 (Adverse Obstetrical Outcomes for Women With Adenomyosis), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adverse Obstetrical Outcomes for Women With Adenomyosis
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Association between adenomyosis and maternal and neonatal outcomes: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Clinical practice guidelines for endometriosis in Japan (The 3rd edition).The journal of obstetrics and gynaecology research · 2022Guideline
- Comparative analysis of low-dose letrozole versus GnRH agonist on implantation markers and IVF outcomes in symptomatic adenomyosis: a randomized trial.Scientific reports · 2025Trial
- Comparative effectiveness of two hysteroscopic fixation techniques (suture vs. GyneFix anchor) for levonorgestrel-releasing intrauterine system: a retrospective study.BMC women's health · 2026Article
- Maternal and Neonatal Outcomes in Pregnancies with Adenomyosis.Maternal and child health journal · 2025Article
- The Impact of Adenomyosis on Pregnancy.Biomedicines · 2024Review
- Clinical Characteristics and Local Histopathological Modulators of Endometriosis and Its Progression.International journal of molecular sciences · 2024Article
- The Impact of Endometriosis on Pregnancy.Journal of personalized medicine · 2024Review
- Impact of adenomyosis on perinatal outcomes: a large cohort study (JSOG database).BMC pregnancy and childbirth · 2023Article
- The Role of Platelets in the Pathogenesis and Pathophysiology of Adenomyosis.Journal of clinical medicine · 2023Review
- In Search of an Imaging Classification of Adenomyosis: A Role for Elastography?Journal of clinical medicine · 2022Review
- Establishment of a novel mouse model of adenomyosis suitable for longitudinal and quantitative analysis and perinatal outcome studies.Scientific reports · 2022Article
- Fertility and Pregnancy Outcomes in Patients With Adenomyosis: Is Adenomyosis Synonymous With Infertility?Cureus · 2022Review
- Endometriosis and preterm birth: A Danish cohort study.Acta obstetricia et gynecologica Scandinavica · 2022Article
- Unveiling the Pathogenesis of Adenomyosis through Animal Models.Journal of clinical medicine · 2022Review
- Difficulty in predicting intra-abdominal adhesion before cesarean section: A case report.Clinical case reports · 2022Article
- Association of preconception dysmenorrhea with obstetric complications: the Japan Environment and Children's Study.BMC pregnancy and childbirth · 2022Article
- Deep Infiltrating Endometriosis and Adenomyosis: Implications on Pregnancy and Outcome.Journal of clinical medicine · 2021Review
- Mutation and methylation profiles of ectopic and eutopic endometrial tissues.The Journal of pathology · 2021Article
- Pregnancy outcomes in women with infertility and coexisting endometriosis and adenomyosis after laparoscopic surgery: a long-term retrospective follow-up study.BMC pregnancy and childbirth · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBecause of the increased number of diagnosed cases of endometriosis or adenomyosis resulting in infertility, many women require assisted reproductive technology (ART) to become pregnant. However, incidences of obstetric complications are increased for women who conceive using ART. There has been no prospective cohort study examining the influence of endometriosis and adenomyosis on obstetric outcomes after adjusting for the confounding influence of ART therapy.
objectiveThis study evaluated the impact of endometriosis and adenomyosis on the incidence of adverse pregnancy outcomes. STUDY
designData were obtained from a prospective cohort study, known as the Japan Environment and Children's Study (JECS), of the incidence of obstetric complications for women with endometriosis and adenomyosis. The data of 103,099 pregnancies that resulted in live birth or stillbirth or that were terminated through abortion between February 2011 and July 2014 in Japan were included.
resultsWomen with endometriosis or adenomyosis were at increased risk for complications during pregnancy compared to those without a medical history of endometriosis (odds ratio [OR], 1.32; 95% confidence interval [CI], 1.23 to 1.41) or adenomyosis (OR, 1.72; 95% CI, 1.37 to 2.16). Our analysis showed that the adjusted ORs for obstetric complications of pregnant women who conceived naturally or after infertility treatment that did not involve ART therapy were 1.26 (CI, 1.17 to 1.35) for pregnant women with a history of endometriosis and 1.52 (CI, 1.19 to 1.94) for those with a history of adenomyosis.
conclusionsThe presence of endometriosis and adenomyosis significantly increased the prevalence of obstetric complications after adjusting for the influence of ART outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.