ArticleEpidemiology (Cambridge, Mass.)2019
An Empirical Validation of the Within-subject Biospecimens Pooling Approach to Minimize Exposure Misclassification in Biomarker-based Studies.
Article in Epidemiology (Cambridge, Mass.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic evidence map on the association between exposure to personal care products and fetal growth.Environment international · 2026Pooled it
- Urinary Glyphosate Concentrations among Pregnant Participants in a Randomized, Crossover Trial of Organic and Conventional Diets.Environmental health perspectives · 2023Trial
- Prenatal and childhood exposure to common plasticizers and risk-taking behavior in young adolescents.Environmental research · 2026Article
- Urinary phthalate metabolite concentrations and oxidative stress biomarkers in pre- and perimenopausal women from the Midlife Women's Health Study.Reproductive toxicology (Elmsford, N.Y.) · 2026Article
- Associations of endocrine disrupting chemicals with anogenital distance across infancy.The Journal of clinical endocrinology and metabolism · 2026Observational
- Associations of Exposure to Common Plasticizers and Organophosphate Pesticides during Pregnancy and in Childhood with Cognitive Performance in Adolescents: A Population-Based Study.Environmental science & technology · 2026Article
- Relevance and challenges of exposome studies for environmental health research.Environmental health : a global access science source · 2026Review
- Evaluating the use of silicone wristbands and urinary biomarkers to assess personal exposure to phthalates.Journal of exposure science & environmental epidemiology · 2026Article
- Causal Covariate Selection for the Regression Calibration Method for Exposure Measurement Error Bias Correction.Statistics in medicine · 2026Article
- Impact of plastic-related chemicals on emotional and behavioral health in children from Poland.Environmental health : a global access science source · 2025Article
- Early-life exposure to a mixture of phenols and respiratory health in preschool children.The European respiratory journal · 2025Article
- Endocrine-Disrupting Chemicals and Persistent Nausea among Pregnant Women Enrolled in the Illinois Kids Development Study (I-KIDS).Environmental health perspectives · 2025Article
- Prenatal Exposure to Synthetic Phenols Assessed in Multiple Urine Samples and Dysregulation of Steroid Hormone Homeostasis in Two European Cohorts.Environmental health perspectives · 2025Article
- Exploring diet as a source of plasticizers in pregnancy and implications for maternal second-trimester metabolic health.Environmental research · 2024Article
- Environmental Phenols and Growth in Infancy: The Infant Feeding and Early Development Study.The Journal of clinical endocrinology and metabolism · 2024Article
- Gestational organophosphate pesticide exposure and childhood cardiovascular outcomes.Environment international · 2024Article
- Longitudinal associations between urinary biomarkers of phthalates and replacements with novel in vivo measures of placental health.Human reproduction (Oxford, England) · 2024Article
- Article
- Fetal and Infancy Exposure to Phenols, Parabens, and Phthalates and Anthropometric Measurements up to 36 Months, in the Longitudinal SEPAGES Cohort.Environmental health perspectives · 2024Article
- Causal Selection of Covariates in Regression Calibration for Mismeasured Continuous Exposure.Epidemiology (Cambridge, Mass.) · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundWithin-subject biospecimens pooling can theoretically reduce bias in dose-response functions from biomarker-based studies when exposure assessment suffers from classical-type error. However, collecting many urine voids each day is cumbersome. We evaluated the empirical validity of a within-subject pooling approach and compared several options to avoid sampling each void.
methodsIn 16 pregnant women who collected a spot of each urine void over several nonconsecutive weeks, we compared concentrations of 10 phenols in daily, weekly, and pregnancy within-subject pools. We pooled either three or all daily samples. In a simulation study using these data, we quantified bias in dose-response functions when using one to 20 urine samples per subject to assess methylparaben (a compound with moderate within-subject variability) and bisphenol A (high variability) exposures.
resultsCorrelations between exposure estimates from pools of all and of only three voids per day were above 0.80 for all time windows and compounds, except for benzophenone-3 and triclosan in the daily time window (correlations, 0.57-0.68). With one spot sample to assess pregnancy exposure, correlations were all below 0.74. Using only one biospecimen led to attenuation bias in the dose-response functions of 29% (methylparaben) and 69% (bisphenol A); four samples for methylparaben and 18 for bisphenol A decreased bias to 10%.
conclusionsFor nonpersistent chemicals, collecting and pooling three samples per day instead of all daily samples efficiently estimates exposures over a week or more. Collecting around 20 biospecimens can strongly limit attenuation bias for nonpersistent chemicals such as bisphenol A.
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