Evidence map›Paper›PMID 31373830›Full record

ArticleThe American journal of sports medicine2019

Comparative Clinical Outcomes After Intra-articular Injection With Adipose-Derived Cultured Stem Cells or Noncultured Stromal Vascular Fraction for the Treatment of Knee Osteoarthritis.

Naomasa Yokota, Mari Hattori, Tadahiko Ohtsuru, Masaki Otsuji, Stephen Lyman, Kazunori Shimomura, Norimasa Nakamura

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Article in The American journal of sports medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 8 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 8 syntheses or guidelines pooled it, 112 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Naomasa YokotaTokyo Knee Osteoarthritis Clinic Ginza, Tokyo, Japan.
Mari HattoriTokyo Knee Osteoarthritis Clinic Ginza, Tokyo, Japan.
Tadahiko OhtsuruTokyo Knee Osteoarthritis Clinic Ginza, Tokyo, Japan.
Masaki OtsujiTokyo Knee Osteoarthritis Clinic Ginza, Tokyo, Japan.
Stephen LymanHospital for Special Surgery, New York, New York, USA.
Kazunori ShimomuraDepartment of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Norimasa NakamuraInstitute for Medical Science in Sports, Osaka Health Science University, Osaka, Japan.
Hospital for Special Surgery · USOsaka Health Science University · JPOsaka University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntra-articular injection of adipose-derived stem cells (ASCs) has shown promise for improving symptoms and cartilage quality in the treatment of osteoarthritis (OA). However, while most preclinical studies have been performed with plastic-adherent ASCs, most clinical trials are being conducted with the stromal vascular fraction (SVF), prepared from adipose tissue without prior culture. PURPOSE: To directly compare clinical outcomes of intra-articular injection with ASCs or SVF in patients with knee OA. STUDY

designCohort study; Level of evidence, 3.

methodsThe authors retrospectively compared 6-month outcomes in 42 patients (59 knees) receiving intra-articular injection with 12.75 million ASCs and 38 patients (69 knees) receiving a 5-mL preparation of SVF. All patients had Kellgren-Lawrence grade 2, 3, or 4 knee OA and had failed standard medical therapy. The visual analog scale (VAS) pain score and Knee injury and Osteoarthritis Outcome Score (KOOS) at baseline and 1, 3, and 6 months after injection were considered as outcomes. Outcome Measures in Rheumatology-Osteoarthritis Research Society International (OMERACT-OARSI) criteria were also used to assess positive response. A repeated measures analysis of variance was used for comparison between the treatment groups.

resultsNo major complications occurred in either group. The SVF group had a higher frequency of knee effusion (SVF 8%, ASC 2%) and minor complications related to the fat harvest site (SVF 34%, ASC 5%). Both groups reported improvements in pain VAS and KOOS domains. Specifically, in the ASC group, symptoms improved earlier (by 3 months;

conclusionIt was observed that both ASCs and SVF resulted in clinical improvement in patients with knee OA, but that ASCs outperform SVF in the early reduction of symptoms and pain with less comorbidity.

Indexed as

Adipose TissueAgedAged, 80 and overCells, CulturedCohort StudiesFemaleHumansInjections, Intra-ArticularKneeMaleMiddle AgedOsteoarthritis, KneeRetrospective StudiesStem Cell TransplantationTreatment Outcomeadipose-derived stem cellsintra-articular injectionknee osteoarthritisstromal vascular fraction

Identifiers

PMID31373830
OpenAlexW2965610321

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.