ArticleeLife2019
Sox1a mediates the ability of the parapineal to impart habenular left-right asymmetry.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Swimming through asymmetry: zebrafish as a model for brain and behavior lateralization.Frontiers in behavioral neuroscience · 2025Review
- The lamprey habenula provides an extreme example for the temporal regulation of asymmetric development.Frontiers in cell and developmental biology · 2025Article
- Analysis of a shark reveals ancient, Wnt-dependent, habenular asymmetries in vertebrates.Nature communications · 2024Article
- Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain.Science (New York, N.Y.) · 2024Article
- Contribution of the eye and of opn4xa function to circadian photoentrainment in the diurnal zebrafish.PLoS genetics · 2024Article
- Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel.Frontiers in cell and developmental biology · 2022Article
- Conserved and diverged asymmetric gene expression in the brain of teleosts.Frontiers in cell and developmental biology · 2022Article
- Ontogenesis of the asymmetric parapineal organ in the zebrafish epithalamus.Frontiers in cell and developmental biology · 2022Article
- Zebrafish Tools for Deciphering Habenular Network-Linked Mental Disorders.Biomolecules · 2021Review
- Brain and Behavioral Asymmetry: A Lesson From Fish.Frontiers in neuroanatomy · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Left-right asymmetries in the zebrafish habenular nuclei are dependent upon the formation of the parapineal, a unilateral group of neurons that arise from the medially positioned pineal complex. In this study, we show that both the left and right habenula are competent to adopt left-type molecular character and efferent connectivity upon the presence of only a few parapineal cells. This ability to impart left-sided character is lost in parapineal cells lacking Sox1a function, despite the normal specification of the parapineal itself. Precisely timed laser ablation experiments demonstrate that the parapineal influences neurogenesis in the left habenula at early developmental stages as well as neurotransmitter phenotype and efferent connectivity during subsequent stages of habenular differentiation. These results reveal a tight coordination between the formation of the unilateral parapineal nucleus and emergence of asymmetric habenulae, ensuring that appropriate lateralised character is propagated within left and right-sided circuitry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.