Evidence map›Paper›PMID 31373533›Full record

ReviewPhysiological genomics2019

Medial prefrontal cortex in neurological diseases.

Pan Xu, Ai Chen, Yipeng Li, Xuezhi Xing, Hui Lu

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Physiological genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed, 9 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

164 citing papers in PubMed, 9 syntheses or guidelines pooled it, 330 citations in OpenAlex.

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  20. Multimodal Layer-Crossing Interrogation of Brain Circuits Enabled by Microfluidic Axialtrodes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article

104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Pan XuDepartment of Pharmacology and Physiology, The George Washington University, Washington, District of Columbia.
Ai ChenDepartment of Pediatrics, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan China.
Yipeng LiDepartment of Biomedical Engineering, The George Washington University, Washington, District of Columbia.
Xuezhi XingDepartment of Pharmacology and Physiology, The George Washington University, Washington, District of Columbia.
Hui LuDepartment of Pharmacology and Physiology, The George Washington University, Washington, District of Columbia.
George Washington University · USAffiliated Hospital of Southwest Medical University · CN

Funding

Mechanisms and rescue of neural circuit dysfunction in Mecp2 mutant miceR00NS089824 · NINDS · GEORGE WASHINGTON UNIVERSITY · PI LU, HUI · 2017 to 2019
$747k
NINDS NIH HHS R00 NS089824
6 · The paper itself

Abstract

The medial prefrontal cortex (mPFC) is a crucial cortical region that integrates information from numerous cortical and subcortical areas and converges updated information to output structures. It plays essential roles in the cognitive process, regulation of emotion, motivation, and sociability. Dysfunction of the mPFC has been found in various neurological and psychiatric disorders, such as depression, anxiety disorders, schizophrenia, autism spectrum disorders, Alzheimer's disease, Parkinson's disease, and addiction. In the present review, we summarize the preclinical and clinical studies to illustrate the role of the mPFC in these neurological diseases.

Indexed as

Alzheimer DiseaseAnimalsAnxiety DisordersAutism Spectrum DisorderDepressionHumansParkinson DiseasePrefrontal CortexSchizophreniaSubstance-Related Disorderscortical regionmedial prefrontal cortexneural circuitneurological diseasepathophysiology

Identifiers

PMID31373533
PMCPMC6766703
OpenAlexW2964824489

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.