Evidence map›Paper›PMID 31373511›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2019

Asynchronous action potential discharge in human muscle sympathetic nerve activity.

Stephen A Klassen, M Erin Moir, Jacqueline K Limberg, Sarah E Baker, Wayne T Nicholson, Timothy B Curry, Michael J Joyner, J Kevin Shoemaker

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. The role of αAmerican journal of physiology. Heart and circulatory physiology · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Central αThe Journal of physiology · 2024
    Article
  6. Article
  7. Advancements in the neurocirculatory reflex response to hypoxia.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Review
  8. Article
  9. The impact of ageing and sex on sympathetic neurocirculatory regulation.Seminars in cell & developmental biology · 2021
    Review
  10. Recording and quantifying sympathetic outflow to muscle and skin in humans: methods, caveats and challenges.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Review
  11. Sympathetic neural recruitment strategies following acute intermittent hypoxia in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stephen A KlassenNeurovascular Research Laboratory, School of Kinesiology, University of Western Ontario, London, Ontario, Canada.
M Erin MoirNeurovascular Research Laboratory, School of Kinesiology, University of Western Ontario, London, Ontario, Canada.
Jacqueline K LimbergDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.
Sarah E BakerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.
Wayne T NicholsonDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.
Timothy B CurryDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.
Michael J JoynerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.
J Kevin ShoemakerNeurovascular Research Laboratory, School of Kinesiology, University of Western Ontario, London, Ontario, Canada.

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Neurovascular Control and Blood Pressure Regulation in HumansR01HL083947 · NHLBI · MAYO CLINIC ROCHESTER · PI JOYNER, MICHAEL J · 2007 to 2016
$3.6M
Reflex responses to intermittent hypoxia in humans: Mechanisms and consequencesR00HL130339 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI LIMBERG, JACQUELINE K · 2017 to 2019
$729k
Reflex responses to intermittent hypoxia in humans: Mechanisms and consequencesK99HL130339 · NHLBI · MAYO CLINIC ROCHESTER · PI LIMBERG, JACQUELINE K · 2016 to 2017
$156k
Improving Drug Delivery In Individuals With Cystic Fibrosis Using ExerciseF32HL131151 · NHLBI · MAYO CLINIC ROCHESTER · PI BAKER, SARAH ELIZABETH · 2016 to 2017
$84k
NCATS NIH HHS UL1 TR000135NHLBI NIH HHS F32 HL131151NHLBI NIH HHS K99 HL130339NHLBI NIH HHS R00 HL130339NHLBI NIH HHS R01 HL083947
6 · The paper itself

Abstract

What strategies are employed by the sympathetic system to communicate with the circulation? Muscle sympathetic nerve activity (MSNA) occurs in bursts of synchronous action potential (AP) discharge, yet whether between-burst asynchronous AP firing exists remains unknown. Using multiunit microneurography and a continuous wavelet transform to isolate APs, we studied AP synchronicity within human MSNA. Asynchronous APs were defined as those which occurred between bursts.

Indexed as

Action PotentialsAdultApneaBaroreflexBlood VesselsFemaleGanglionic BlockersHumansLower Body Negative PressureMaleMuscle, SkeletalNicotinic AntagonistsSympathetic Nervous SystemTime FactorsTrimethaphanYoung AdultGanglionic BlockersNicotinic AntagonistsTrimethaphanaction potentialasynchronous dischargemicroneurographymuscle sympathetic nerve activityparavertebral gangliasympathetic nervous systemsympathetic neural recruitment

Identifiers

PMID31373511
PMCPMC6843011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.