Evidence map›Paper›PMID 31373315›Full record

ArticlePharmaceuticals (Basel, Switzerland)2019

Anxiolytic and Antidepressant Effects of the Hydroethanolic Extract from the Leaves of

Nayara Costa de Melo, Brenda Lorena Sánchez-Ortiz, Tafnis Ingret Dos Santos Sampaio, Arlindo César Matias Pereira, Fernando Luiz Pinheiro da Silva Neto, Heitor Ribeiro da Silva, Rodrigo Alves Soares Cruz, Hady Keita, Ana Maria Soares Pereira, José Carlos Tavares Carvalho

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Varivax (IBRO neuroscience reports · 2026
    Article
  6. Article
  7. ACS chemical neuroscience · 2025
    Article
  8. Review
  9. Hydroethanolic extracts fromPharmaceutical biology · 2024
    Article
  10. Article
  11. Teleosts as behaviour test models for social stress.Frontiers in behavioral neuroscience · 2023
    Review
  12. In Vivo Antidepressant-Like Effect Assessment of TwoMolecules (Basel, Switzerland) · 2022
    Article
  13. Review
  14. Article
  15. Article
  16. Hypoglycemic Activity of Aqueous Extract of Latex fromPharmaceuticals (Basel, Switzerland) · 2021
    Article
  17. Article
  18. Article
  19. Acute Toxicity of the Hydroethanolic Extract of the Flowers ofPharmaceuticals (Basel, Switzerland) · 2019
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Nayara Costa de MeloLaboratório de Pesquisa em Fármacos, Curso de Farmácia, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Macapá, Amapá, CEP 68.903-419, Brasil.ORCID 0000-0002-7166-9460
Brenda Lorena Sánchez-OrtizLaboratório de Pesquisa em Fármacos, Curso de Farmácia, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Macapá, Amapá, CEP 68.903-419, Brasil.ORCID 0000-0002-8442-5908
Tafnis Ingret Dos Santos SampaioLaboratório de Pesquisa em Fármacos, Curso de Farmácia, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Macapá, Amapá, CEP 68.903-419, Brasil.
Arlindo César Matias PereiraLaboratório de Pesquisa em Fármacos, Curso de Farmácia, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Macapá, Amapá, CEP 68.903-419, Brasil.ORCID 0000-0001-9504-5081
Fernando Luiz Pinheiro da Silva NetoLaboratório de Pesquisa em Fármacos, Curso de Farmácia, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Macapá, Amapá, CEP 68.903-419, Brasil.
Heitor Ribeiro da SilvaLaboratório de Pesquisa em Fármacos, Curso de Farmácia, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Macapá, Amapá, CEP 68.903-419, Brasil.
Rodrigo Alves Soares CruzLaboratório de Pesquisa em Fármacos, Curso de Farmácia, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Macapá, Amapá, CEP 68.903-419, Brasil.ORCID 0000-0003-1728-4145
Hady KeitaUniversidad de la Sierra Sur, Division de Pós-Grado, Instituto de Investigación Sobre la Salud Pública, Ciudad Universitaria, Oaxaca, C.P. 70800, México.ORCID 0000-0001-9168-8995
Ana Maria Soares PereiraDepartamento de Biotecnologia em Plantas Medicinais, Universidade de Ribeirão Preto (UNAERP), Ribeirão Preto, São Paulo, CEP 14096-900, Brasil.
José Carlos Tavares CarvalhoLaboratório de Pesquisa em Fármacos, Curso de Farmácia, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Macapá, Amapá, CEP 68.903-419, Brasil. farmacos@unifap.br.ORCID 0000-0003-3662-9794
Universidade Federal do Amapá · BRUniversidade de Ribeirão Preto · BRUniversidad de la Sierra · MX

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico RAPBioFar Proc. 407768/2013-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior PROCAD-Amazonia Proc. 88887.200554/2018-00
6 · The paper itself

Abstract

Medicinal plants such as

Indexed as

Aloysia polystachyaantidepressantanxiolyticDanio rerio

Identifiers

PMID31373315
PMCPMC6789669
OpenAlexW2961150688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.