ArticleNanomaterials (Basel, Switzerland)2019
Lignin-Based Hollow Nanoparticles for Controlled Drug Delivery: Grafting Preparation Using β-Cyclodextrin/Enzymatic-Hydrolysis Lignin.
Article in Nanomaterials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Cyclodextrin: Dual Functions as a Therapeutic Agent and Nanocarrier for Regulating Cholesterol Homeostasis in Atherosclerosis.Pharmaceutics · 2025Review
- Lignin Nanoparticles as pH-responsive Nanocarriers for Gastric-Irritant Oral Drug Aspirin.Current drug delivery · 2025Article
- Biopolymer-Based Nanomedicine for Cancer Therapy: Opportunities and Challenges.International journal of nanomedicine · 2024Review
- Lignins as Promising Renewable Biopolymers and Bioactive Compounds for High-Performance Materials.Polymers · 2023Review
- Review
- How far is Lignin from being a biomedical material?Bioactive materials · 2022Review
- Lignin Nanoparticles and Alginate Gel Beads: Preparation, Characterization and Removal of Methylene Blue.Nanomaterials (Basel, Switzerland) · 2022Article
- Self-assembled/composited lignin colloids utilizing for therapy, cosmetics and emulsification.Frontiers in chemistry · 2022Review
- Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin.International journal of nanomedicine · 2022Review
- Hybrid Tellurium-Lignin Nanoparticles with Enhanced Antibacterial Properties.ACS applied materials & interfaces · 2021Article
- Lignin Nanoparticles: A Promising Tool to Improve Maize Physiological, Biochemical, and Chemical Traits.Nanomaterials (Basel, Switzerland) · 2021Article
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Authors and funding
5 authors.
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Abstract
Due to its abundance, degradability, and low toxicity, lignin is a promising raw material for the preparation of nanomaterials. However, efficient encapsulation using lignin-nanomaterial for sustained-release medications remains a challenge. This study involves grafting β-cyclodextrin (β-CD), with a hollow toroidal structure, onto the enzymatic-hydrolysis lignin (EHL) to form CD-EHL. The modified lignin was next used to prepare hollow nanoparticles (LHNPs) via self-assembly to encapsulate the antitumor drug hydroxycamptothecin (HCPT). The results indicated that β-CD improved the network structure of modified lignin molecules. Moreover, LHNPs that self-assembled using CD-EHL had an increased specific surface area and greater porosity, and exhibited a spherical hollow structure and stability in phosphate-buffered saline. The drug loading and encapsulation efficiency of HCPT were 70.6 ± 9% and 22.02 ± 2%, respectively. An
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