ArticleTherapeutic advances in respiratory disease
Long-term follow up after endoscopic valve therapy in patients with severe emphysema.
Article in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Bronchoscopic endobronchial valves.Breathe (Sheffield, England) · 2026Review
- Multidisciplinary Evaluation for COPD Management.Respiratory care · 2025Article
- Short-Term Outcomes of Bronchoscopic Thermal Vapor Ablation in Patients with Severe COPD: A Case Series from a Single Chinese Center.International journal of chronic obstructive pulmonary disease · 2025Observational
- Long Term Efficacy and Safety of Bronchoscopic Thermal Vapor Ablation in Patients with COPD: A Retrospective Study of 50 Patients.International journal of chronic obstructive pulmonary disease · 2025Observational
- Two-year Results of Bronchoscopic Lung Volume Reduction Using One-Way Endobronchial Valves: Real-World Single Center Data.International journal of chronic obstructive pulmonary disease · 2025Article
- Delayed targeted atelectasis in a case of bronchoscopic lung volume reduction with endobronchial valves.BMJ case reports · 2024Article
- Surgical and bronchoscopic pulmonary function-improving procedures in lung emphysema.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Long-term follow-up after bronchoscopic lung volume reduction valve treatment for emphysema.ERJ open research · 2022Article
- Long-Term Follow-Up of Intralobar Bullae After Endobronchial Valve Treatment for Emphysema.International journal of chronic obstructive pulmonary disease · 2022Article
- Implementation of Bronchoscopic Lung Volume Reduction Using One-Way Endobronchial Valves: A Retrospective Single-Centre Cohort Study.Respiration; international review of thoracic diseases · 2022Article
- Clinical Impact of Compensatory Hyperinflation of the Nontreated Adjacent Lobe After Bronchoscopic Lung Volume Reduction with Valves.International journal of chronic obstructive pulmonary disease · 2022Article
- Lung volume reduction in emphysema: a pragmatic prospective cohort study.ERJ open research · 2021Article
- Bronchoscopic management of asthma, COPD and emphysema.European respiratory review : an official journal of the European Respiratory Society · 2021Article
- Two-Stage Bronchoscopic Endobronchial Valve Treatment Can Lead to Progressive Lung Volume Reduction and May Decrease Pneumothorax Risk.International journal of chronic obstructive pulmonary disease · 2021Article
- Comparative analysis of pulmonary function decline in patients undergoing bronchoscopic lung volume reduction with endobronchial valves versus conservative treatment in emphysema management: A longitudinal coarsened exact matched analysis.Chronic respiratory diseaseArticle
- Bronchoscopic interventions for emphysema: Current status.Lung India : official organ of Indian Chest SocietyReview
- Predictive value of Chartis measurement for lung function improvements in bronchoscopic lung volume reduction.Therapeutic advances in respiratory diseaseArticle
- Severe Emphysema Treated with Bilateral Lung Sealant: A Case Series with Long-Term Follow-Up.Biomedicine hubArticle
- Effect of Endobronchial Coils on Exercise Tolerance and Lung Functions in Patients with Severe Emphysema - A Retrospective Cohort Study of 48 Patients.International journal of chronic obstructive pulmonary diseaseArticle
- Dual-Energy Computed Tomography Compared to Lung Perfusion Scintigraphy to Assess Pulmonary Perfusion in Patients Screened for Endoscopic Lung Volume Reduction.Respiration; international review of thoracic diseasesArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveEndoscopic valve therapy is a treatment modality in patients with advanced emphysema and absent interlobar collateral ventilation (CV). So far, long-term outcome following valve implantation has been insufficiently evaluated. The aim of this study was to investigate the real-world efficacy of this interventional therapy over 3 years.
methodsFrom 2006 to 2013, 256 patients with severe emphysema in whom absent CV was confirmed underwent valve therapy. The 3-year effectiveness was evaluated by pulmonary function testing (VC, FEV
resultsOf 256 patients treated with valves, 220, 200, 187, 100 and 66 patients completed the 3-month, 6-month, 1-year, 2-year and 3-year follow-up (FU) visit, respectively. All lung function parameters, 6-MWT and mMRC were significantly improved at 3- and 6-month FU. At 1-year FU, patients still experienced a significant improvement of all outcome parameters expect VC (L) and TLC (%). At 2 years, RV (L and %) and TLC (L and %) remained significantly improved compared to baseline. Three years after valve therapy, sustained significant improvement in mMRC was observed and the proportion of patients achieving a minimal clinically important difference from baseline in RV and 6-MWT was still 71% and 46%, respectively. Overall, patients with complete lobar atelectasis exhibited superior treatment outcome with 3-year responder rates to FEV
conclusionsPatients treated by valves experienced clinical improvement over 1 year following valve therapy. Afterwards, clinical benefit gradually declines more likely due to COPD progression.
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