Evidence map›Paper›PMID 31373242›Full record

ArticleCell cycle (Georgetown, Tex.)2019

Circular RNA circ_0000950 promotes neuron apoptosis, suppresses neurite outgrowth and elevates inflammatory cytokines levels via directly sponging miR-103 in Alzheimer's disease.

Hui Yang, Huan Wang, Hong Shang, Xiufen Chen, Shiqi Yang, Yang Qu, Jing Ding, Xuling Li

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 90 citations in OpenAlex.

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  9. Circular RNAs in Brain Physiology and Neurologic Diseases.Advances in experimental medicine and biology · 2025
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hui YangDepartment of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin Medical University , Harbin , China.
Huan WangDepartment of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin Medical University , Harbin , China.
Hong ShangDepartment of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin Medical University , Harbin , China.
Xiufen ChenDepartment of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin Medical University , Harbin , China.
Shiqi YangDepartment of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin Medical University , Harbin , China.
Yang QuDepartment of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin Medical University , Harbin , China.
Jing DingDepartment of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin Medical University , Harbin , China.
Xuling LiDepartment of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin Medical University , Harbin , China.ORCID 0000-0001-8664-0284
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the effect of circ_0000950/miR-103 network on regulating neuron apoptosis, neurite outgrowth and inflammation in Alzheimer's disease (AD). Cellular AD model of rat pheochromocytoma cell line PC12 cells and cellular AD model of rat cerebral cortex neurons were constructed, and the effect of circ_0000950 on apoptosis, neurite outgrowth and inflammation in both cellular AD models was determined through upregulation and knockdown of circ_0000950 expression by transfection. Compensation experiments and luciferase assay were further performed to validate the sponging effect of circ_0000950 on miR-103 as well as the mechanisms of circ_0000950/miR-103 on regulating apoptosis, neurite outgrowth and inflammation in both cellular AD models. Circ_0000950 reduced miR-103 expression and increased prostaglandin-endoperoxide synthase 2 (PTGS2) expression in both two cellular AD models. And circ_0000950 overexpression promoted neuron apoptosis, suppressed neurite outgrowth and elevated IL-1β, IL-6 and TNF-α levels compared with overexpression control, whereas circ_0000950 knockdown inhibited neuron apoptosis, enhanced neurite outgrowth and lowered IL-1β, IL-6 and TNF-α levels compared with shRNA control in both two cellular AD models. Compensation experiments along with luciferase reporter assay validated that circ_0000950 promoted cell apoptosis, suppressed neurite outgrowth and elevated inflammatory cytokines levels via directly sponging miR-103. In conclusion, circ_0000950 promotes neuron apoptosis, suppresses neurite outgrowth and elevates inflammatory cytokines levels through directly sponging miR-103 in AD.

Indexed as

Alzheimer DiseaseAnimalsApoptosisCyclooxygenase 2CytokinesDisease Models, AnimalHEK293 CellsHumansInflammationMicroRNAsNeuritesNeuronal OutgrowthPC12 CellsRatsRNA, CircularSignal TransductionCyclooxygenase 2CytokinesMicroRNAsMIRN103 microRNA, ratPtgs2 protein, ratRNA, CircularAlzheimer’s diseaseapoptosisCirc_0000950

Identifiers

PMID31373242
PMCPMC6738533
OpenAlexW2966433496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.