ArticleCell proliferation2019
An extravascular fluid transport system based on structural framework of fibrous connective tissues in human body.
Article in Cell proliferation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Revolutionizing the understanding of acupoint biology and acupuncture mechanisms through spatial omics: current perspectives and future directions.Frontiers in medicine · 2026Review
- Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration.iScience · 2024Article
- Article
- A robust MRI contrast agent for specific display of the interstitial stream.Nanoscale advances · 2023Article
- Interstitial Fluid Flows along Perivascular and Adventitial Clearances around Neurovascular Bundles.Journal of functional biomaterials · 2022Article
- Interstitial Fluid Behavior and Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Layers of interstitial fluid flow along a "slit-shaped" vascular adventitia.Journal of Zhejiang University. Science. B · 2021Article
- Fascial Nomenclature: Update 2021, Part 2.Cureus · 2021Review
- Active interfacial dynamic transport of fluid in a network of fibrous connective tissues throughout the whole body.Cell proliferation · 2020Review
- An extravascular fluid transport system based on structural framework of fibrous connective tissues in human body.Cell proliferation · 2019Article
Corrections and comments
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Authors and funding
21 authors.
Funding
Abstract
objectiveInterstitial fluid in extracellular matrices may not be totally fixed but partially flow through long-distance oriented fibrous connective tissues via physical mechanisms. We hypothesized there is a long-distance interstitial fluid transport network beyond vascular circulations. MATERIALS AND
methodsWe first used 20 volunteers to determine hypodermic entrant points to visualize long-distance extravascular pathway by MRI. We then investigated the extravascular pathways initiating from the point of thumb in cadavers by chest compressor. The distributions and structures of long-distance pathways from extremity ending to associated visceral structures were identified.
resultsUsing fluorescent tracer, the pathways from right thumb to right atrium wall near chest were visualized in seven of 10 subjects. The cutaneous pathways were found in dermic, hypodermic and fascial tissues of hand and forearm. The perivascular pathways were along the veins of arm, axillary sheath, superior vena cava and into the superficial tissues on right atrium. Histological and micro-CT data showed these pathways were neither blood nor lymphatic vessels but long-distance oriented fibrous matrices, which contained the longitudinally assembled micro-scale fibres consistently from thumb to superficial tissues on right atrium.
conclusionsThese data revealed the structural framework of the fibrous extracellular matrices in oriented fibrous connective tissues was of the long-distance assembled fibres throughout human body. Along fibres, interstitial fluid can systemically transport by certain driving-transfer mechanisms beyond vascular circulations.
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