Evidence map›Paper›PMID 31372986›Full record

ArticleDevelopmental psychobiology2020

Relations between catechol-O-methyltransferase Val158Met genotype and inhibitory control development in childhood.

Maureen E Bowers, George A Buzzell, Virginia Salo, Sonya V Troller-Renfree, Colin A Hodgkinson, David Goldman, Elena Gorodetsky, Jennifer Martin McDermott, Heather A Henderson, Nathan A Fox

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In one paragraph

Article in Developmental psychobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Maureen E BowersNeuroscience and Cognitive Science Program, University of Maryland, College Park, MD, USA.ORCID 0000-0002-4233-723X
George A BuzzellDepartment of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, USA.
Virginia SaloDepartment of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, USA.ORCID 0000-0002-4270-102X
Sonya V Troller-RenfreeDepartment of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, USA.
Colin A HodgkinsonLaboratory of Neurogenetics, Intramural Research Program, The National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
David GoldmanLaboratory of Neurogenetics, Intramural Research Program, The National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
Elena GorodetskyOffice of Research on Women's Health, The National Institute of Health, Bethesda, MD, USA.
Jennifer Martin McDermottDepartment of Psychological & Brain Sciences, University of Masssachusetts, Amherst, MA, USA.
Heather A HendersonDepartment of Psychology, University of Waterloo, Waterloo, ON, Canada.
Nathan A FoxNeuroscience and Cognitive Science Program, University of Maryland, College Park, MD, USA.
University of Maryland, College Park · USNational Institute on Alcohol Abuse and Alcoholism · USOffice of the Director · USUniversity of Massachusetts Amherst · USUniversity of Waterloo · CA

Funding

Integrative genetics of behavior with high throughput technologiesZIAAA000301 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI GOLDMAN, DAVID · 2009 to 2025
$68.6M
Trajectories of Behavioral Inibition and Risk for AnxietyU01MH093349 · NIMH · UNIV OF MARYLAND, COLLEGE PARK · PI FOX, NATHAN A · 2011 to 2020
$6.6M
NIMH NIH HHS U01 MH093349
6 · The paper itself

Abstract

The Val158Met rs4680 single-nucleotide polymorphism (SNP) at the catechol-O-methyltransferase (COMT) gene, primarily involved in dopamine breakdown within prefrontal cortex, has shown relations with inhibitory control (IC) in both adults and children. However, little is known about how COMT genotype relates to developmental trajectories of IC throughout childhood. Here, our study explored the effects of the COMT genotype (Val/Val, Val/Met, and Met/Met) on IC trajectories between the ages of 5 and 10 years. Children (n = 222) completed a Go/Nogo task at ages 5, 7, and 10; IC was characterized using signal detection theory to examine IC performance (d') and response strategy (RS) (criterion). COMT genotype was not related to initial levels of IC performance and RS at age 5 or change in RS from ages 5 to 10. In contrast, COMT genotype was related to change in IC performance between 5 and 10 years. While Val/Val children did not differ from Val/Met children in development of IC performance, children with the Met/Met genotype exhibited more rapid development of IC performance when compared with Val/Met peers. These results suggest that COMT genotype modulates the development of IC performance in middle childhood.

Indexed as

Inhibition, PsychologicalCatechol O-MethyltransferaseChildChild DevelopmentChild, PreschoolExecutive FunctionFemaleGenotypeHumansLongitudinal StudiesMalePolymorphism, Single NucleotidePsychomotor PerformanceCatechol O-MethyltransferaseCOMT protein, humanchildhood developmentCOMTGo/Nogo taskinhibitory controlrs4680signal detection theory

Identifiers

PMID31372986
PMCPMC6994372
OpenAlexW2965332398

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.