ArticleMolecular diagnosis & therapy2019
Salivary Total Protease Activity Based on a Broad-Spectrum Fluorescence Resonance Energy Transfer Approach to Monitor Induction and Resolution of Gingival Inflammation.
Article in Molecular diagnosis & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Probiotics Augment the Effect of Non-Surgical Periodontal Treatment-A Randomised, Double-Blinded, Placebo-Controlled Trial.Journal of clinical periodontology · 2026Trial
- Probiotics Partly Suppress the Impact of Sugar Stress on the Oral Microbiota-A Randomized, Double-Blinded, Placebo-Controlled Trial.Nutrients · 2023Trial
- Trial
- A review of the wide applications of microfluidic devices in peri-implantitis, periodontitis, and endodontics.Odontology · 2026Review
- Latex Fruit Syndrome and Periodontitis - A Missing Link.Journal of pharmacy & bioallied sciences · 2024Review
- Saliva Collection Methods Among Children and Adolescents: A Scoping Review.Molecular diagnosis & therapy · 2024Article
- A GMR enzymatic assay for quantifying nuclease and peptidase activity.Frontiers in bioengineering and biotechnology · 2024Article
- The effect of sex steroid hormones on the ecology ofBiofilm · 2023Article
- Precision periodontal care: from omics discoveries to chairside diagnostics.Clinical oral investigations · 2023Review
- Salivary secretory leukocyte protease inhibitor levels in patients with stage 3 grade C periodontitis: a comparative cross-sectional study.Scientific reports · 2022Article
- Salivary Assessments in Post-Liver Transplantation Patients.Journal of clinical medicine · 2022Article
- Salivary Enzymatic Activity and Carious Experience in Children: A Cross-Sectional Study.Children (Basel, Switzerland) · 2022Article
- Salivary biomarkers as key to monitor personalized oral healthcare and precision dentistry: A scoping review.Frontiers in oral health · 2022Article
- Comparing periodontitis biomarkers in saliva, oral rinse and gingival crevicular fluid: A pilot study.Journal of clinical periodontology · 2021Article
- Validation and verification of predictive salivary biomarkers for oral health.Scientific reports · 2021Article
- Salivary proteotypes of gingivitis tolerance and resilience.Journal of clinical periodontology · 2020Article
- Elevated Baseline Salivary Protease Activity May Predict the Steadiness of Gingival Inflammation During Periodontal Healing: A 12-Week Follow-Up Study on Adults.Pathogens (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSalivary total protease and chitinase activities were measured by a broad-spectrum fluorescence resonance energy transfer approach as predictors of induction and resolution of gingival inflammation in healthy individuals by applying an experimental human gingivitis model.
methodsDental biofilm accumulated (21 days, Induction Phase) by omitting oral hygiene practices followed by a 2-week Resolution Phase to restore gingival health in an experimental gingivitis study. Plaque accumulation, as assessed by the Turesky Modification of the Quigley-Hein Plaque Index (TQHPI), and gingival inflammation, assessed using the Modified Gingival Index (MGI), scores were recorded and unstimulated saliva was collected weekly. Saliva was analysed for total protein, albumin, total protease activity and chitinase activity (n = 18).
resultsThe TQHPI and MGI scores, as well as total protease activity, increased until day 21. After re-establishment of oral hygiene, gingival inflammation levels returned to values similar to baseline (day 0). Levels of protease activity decreased significantly, but not to baseline values. Furthermore, 'fast' responders, who responded immediately to plaque, exhibited significantly higher proteolytic activity throughout the experimental course than 'slow' responders, who showed a lagged inflammatory response.
conclusionThe results indicate that differential inflammatory responses encompass inherent variations in total salivary proteolytic activities, which could be further utilised in contemporary diagnostic, prognostic and treatment modalities for periodontal diseases.
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