ArticleVirus genes2019
High genetic diversity and recombination events of porcine astrovirus strains identified from ill and asymptomatic pigs in 2017, Hunan Province, China.
Article in Virus genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 22 citations in OpenAlex.
- Porcine astrovirus: a review.Archives of virology · 2026Review
- Molecular insights into astrovirus, kobuvirus and rotavirus a coinfection in pigs (Sus domesticus) from Haryana, India.Tropical animal health and production · 2026Article
- Metagenomic characterization of the porcine respiratory virome on farms in northern Kazakhstan.Frontiers in veterinary science · 2026Article
- Isolation and Pathogenicity of a Chinese Porcine Astrovirus Type 5 Strain HNPDS-01 and Its Influence on Cecum Microbiota in Piglets.Transboundary and emerging diseases · 2024Article
- Identification of a Novel Astrovirus Associated with Bovine Respiratory Disease.Transboundary and emerging diseases · 2023Article
- Application of shotgun metagenomics sequencing and targeted sequence capture to detect circulating porcine viruses in the Dutch-German border region.Transboundary and emerging diseases · 2022Article
- Genomic Divergence Characterization and Quantitative Proteomics Exploration of Type 4 Porcine Astrovirus.Viruses · 2022Article
- Epidemiological investigation and genetic characterization of porcine astrovirus genotypes 2 and 5 in Yunnan province, China.Archives of virology · 2022Article
- Epidemiology of Astrovirus, Norovirus and Sapovirus in Greek pig farms indicates high prevalence of Mamastrovirus suggesting the potential need for systematic surveillance.Porcine health management · 2022Article
- Article
- Case Report: First Report and Phylogenetic Analysis of Porcine Astroviruses in Chile.Frontiers in veterinary science · 2021Article
- Establishment of a Multiplex RT-PCR Method for the Detection of Five Known Genotypes of Porcine Astroviruses.Frontiers in veterinary science · 2021Article
- Identification and Characterization of a Novel Recombinant Porcine Astrovirus from Pigs in Anhui, China.Polish journal of microbiology · 2020Article
- Coinfection and Genetic Characterization of Porcine Astrovirus in Diarrheic Piglets in China From 2015 to 2018.Frontiers in veterinary science · 2020Article
- Molecular epidemiology and viremia of porcine astrovirus in pigs from Guangxi province of China.BMC veterinary research · 2019Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Astroviruses (AstV) are associated with enteric and systemic disease in mammals and birds. Astroviruses have received increased attention recently as they have been found to be associated with sporadic neurologic disease in mammals including humans. In pigs, porcine astrovirus (PoAstV) can be widely detected and has been grouped in five genotypes (PoAstV1 to PoAstV5). In the present study, we detected multiple PoAstVs in serum samples, nasal swabs, and fecal swabs collected from pigs suffering from respiratory disease or diarrhea but also from asymptomatic pigs, indicating a wide tissue tropism of the identified PoAstV genotypes. Coinfection of different genotypes in the same pig was commonly observed, and within an individual pig a high genetic diversity was observed for viruses belonging to the same PoAstV genotype. Two complete genomes of PoAstV2-WG-R2/2017 and PoAstV4-WG-R2/2017 were successfully obtained and characterized, with genome sizes of 6396 and 6643 nucleotides, respectively. The PoAstV2-WG-R2/2017 genome showed identities of 67.2-77.4% to other known PoAstV2 genomes, and the PoAstV4-WG-R2/2017 genome showed identities of 72.8-80.5% to other known PoAstV4 genomes. The predicted spike domain of open reading frame 2 (ORF2) of these strains showed the highest genetic heterogeneity, with amino acid identities of 13.7-70.9% for PoAstV2-WG-R2/2017 to other known PoAstV2 strains, and identities of 24.4-63.3% for the PoAstV4-WG-R2/2017 to other known PoAstV4 strains. Possible recombination events were identified in each of the two sequences. Two subclades of PoAstV2 and three subclades of PoAstV4 were defined in the present analyses. The obtained data provide further evidence for extraintestinal infectivity of PoAstVs, and confirmed the high genetic diversity of PoAstVs and the coinfection potential of different PoAstV types in a single pig.
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