Evidence map›Paper›PMID 31372912›Full record

ArticleDigestive diseases and sciences2020

Readmission Rates and Associated Outcomes for Alcoholic Hepatitis: A Nationwide Cohort Study.

Adeyinka C Adejumo, George Cholankeril, Umair Iqbal, Eric R Yoo, Brian C Boursiquot, Waldo C Concepcion, Donghee Kim, Aijaz Ahmed

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  14. Epidemiology and Disease Burden of Alcohol Associated Liver Disease.Journal of clinical and experimental hepatology
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Adeyinka C AdejumoDepartment of Medicine, North Shore Medical Center, 81 Highland Ave., Salem, MA, 01970, USA. acadejumo@partners.org.ORCID 0000-0001-5144-4064
George CholankerilDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, USA.
Umair IqbalDepartment of Medicine, Geisinger Medical Center, Danville, PA, USA.
Eric R YooDepartment of Internal Medicine, Santa Clara Valley Medical Center, San Jose, CA, USA.
Brian C BoursiquotDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, USA.
Waldo C ConcepcionDepartment of Surgery, Abdominal Transplantation, Stanford University School of Medicine, Stanford, CA, USA.
Donghee KimDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, USA.
Aijaz AhmedDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, USA.

Funding

TRAINING GRANT IN ACADEMIC GASTROENTEROLOGYT32DK007056 · NIDDK · STANFORD UNIVERSITY · PI Natalie J. Torok · 1986 to 2026
$6.5M
NIDDK NIH HHS T32 DK007056
6 · The paper itself

Abstract

BACKGROUND/

aimsAlcoholic hepatitis (AH) can lead to sudden and severe hepatic decompensation necessitating recurrent hospitalizations. We evaluated the trends, predictors, and healthcare cost burden of AH-related readmissions in the USA.

methodsUtilizing the National Readmissions Database 2010-2014, we performed a retrospective longitudinal analysis to identify the index readmission with AH for up to 90 days after discharge. Annual trends of 30- and 90-day AH-related readmissions were calculated. Predictors of 30- and 90-day readmission were determined by multivariate logistic regression. Annual healthcare cost burden associated with AH-linked readmissions was estimated.

resultsOf the 21,572 (unweighted: 50,769) AH-related hospitalizations, 4917 (22.8%) and 7890 (36.6%) were readmitted in 30 and 90 day, respectively, with rates that were statistically unchanged from 2010 to 2014. Predictors of 30-day readmissions included female gender, hepatitis C virus infection, cirrhosis, ascites, acute kidney injury, urinary tract infection, history of bariatric surgery, chronic pancreatitis, and high medical comorbidity index. Acute pancreatitis and palliative care consultation were associated with a lower risk of 30-day readmission. Predictors of 90-day readmission were similar to risk factors for 30-day readmission. From 2010 to 2014, the annual cost (and total hospitalization days) burden increased in 2014 to $164 million (22,244 days) and $321 million (42,772 days) for 30- and 90-day AH-related readmissions, respectively.

conclusionDespite relatively stable trends in AH-related readmission, the total LOS and cost has been rising. A target-directed approach with a focus on high-risk subpopulations may help understand the unique challenges associated with the rising cost of AH-related readmissions.

Indexed as

AdultCohort StudiesFemaleHepatitis, AlcoholicHumansLongitudinal StudiesMaleMiddle AgedPatient ReadmissionRetrospective StudiesTreatment OutcomeUnited StatesCostLength of stayPredictorsRateTrends

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.