Evidence map›Paper›PMID 31372847›Full record

ReviewCurrent pain and headache reports2019

Recent Advances in the Understanding and Management of Carpal Tunnel Syndrome: a Comprehensive Review.

Ivan Urits, Kyle Gress, Karina Charipova, Vwaire Orhurhu, Alan D Kaye, Omar Viswanath

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Current pain and headache reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07070661 (Effects of Radial Pressure Wave Therapy Modulation in Patients With Carpal Tunnel Syndrome), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07070661 nacompletednot on this mapstarted 2025, after this paper: background citation

Effects of Radial Pressure Wave Therapy Modulation in Patients With Carpal Tunnel Syndrome: A Double-Blind Randomized Clinical Trial.

TypeinterventionalSponsorArmando Tonatiuh Avila GarciaRan2025 to 2026Enrolled60ConditionsCarpal Tunnel Syndrome (CTS)ArmsFixed-Dose Radial Pressure Wave Therapy., Modulated-Dose Radial Pressure Wave Therapy.
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Evaluation of Endoscopic Release for Carpal Tunnel Syndrome.Plastic and reconstructive surgery. Global open · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Blocking CTGF/CCN2 reverses neural fibrosis and sensorimotor declines in a rat model of overuse-induced median mononeuropathy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Ivan UritsBeth Israel Deaconess Medical Center, Department of Anesthesia, Critical Care, and Pain Medicine, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA. iurits@bidmc.harvard.edu.
Kyle GressGeorgetown University School of Medicine, Washington, DC, USA.
Karina CharipovaGeorgetown University School of Medicine, Washington, DC, USA.
Vwaire OrhurhuBeth Israel Deaconess Medical Center, Department of Anesthesia, Critical Care, and Pain Medicine, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.
Alan D KayeDepartment of Anesthesiology, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Omar ViswanathValley Anesthesiology and Pain Consultants, Phoenix, AZ, USA.
Beth Israel Deaconess Medical Center · USGeorgetown University · USCreighton University · USLouisiana State University Health Sciences Center New Orleans · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewCarpal tunnel syndrome (CTS) is an entrapment neuropathy that involves the compression of the median nerve at the wrist and is considered the most common of all focal entrapment mononeuropathies. CTS makes up 90% of all entrapment neuropathies diagnosed in the USA and affects millions of Americans. RECENT

findingsAge and gender likely play a role in the development of CTS, but additional studies may further elucidate these associations. Of known associated risk factors, diabetes mellitus seems to have the greatest association with CTS. One of the most commonly reported symptoms in CTS is a "pins-and-needles" sensation in the first three fingers and nocturnal burning pain that is relieved with activity upon waking. Treatment for CTS is variable depending on the severity of symptoms. Conservative management of CTS is usually considered first-line therapy. In cases of severe sensory or motor deficit, injection therapy or ultimately surgery may then be considered. Still CTS is often difficult to treat and may be reoccurring. Novel treatment modalities such as laser and shockwave therapy have demonstrated variable efficacy though further studies are needed to assess for safety and effect. Given the unknown and potentially complex etiology of CTS, further studies are needed to explore combinations of diagnostic and therapeutic modalities.

Indexed as

Carpal Tunnel SyndromeHumansMedian NerveNerve Compression SyndromesPainRisk FactorsWristCarpal tunnel syndromeChronic pain managementEndoscopic releaseEntrapment neuropathyInjection therapy

Identifiers

PMID31372847
OpenAlexW2966796724

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.