ArticleMedical & biological engineering & computing2019
Biomechanical modeling of transcatheter aortic valve replacement in a stenotic bicuspid aortic valve: deployments and paravalvular leakage.
Article in Medical & biological engineering & computing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Pooled-Analysis of Association of Sievers Bicuspid Aortic Valve Morphology With New Permanent Pacemaker and Conduction Abnormalities After Transcatheter Aortic Valve Replacement.Frontiers in cardiovascular medicine · 2022Pooled it
- Feasibility of large-scale in silico transcatheter aortic valve implantation trials using a fast-to-evaluate model.Biomechanics and modeling in mechanobiology · 2026Article
- Mechanical Behavior of Valve Stents in Diverse Bicuspid Aortic Valves: Influence of Structural Design and Annular Eccentricity.Cardiovascular engineering and technology · 2026Article
- Computational modelling for personalized transcatheter aortic valve replacement planning: a systematic review of complications and decision support.Frontiers in digital health · 2026Review
- Predicting procedural outcomes in transcatheter aortic valve implantation: a scoping review of numerical patient-specific simulations.Progress in biomedical engineering (Bristol, England) · 2025Article
- [Structural design and mechanical analysis of a "drum-shaped" balloon-expandable valve stent in expanded configuration].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Article
- Finite Element Analysis of Evolut Transcatheter Heart Valves: Effects of Aortic Geometries and Valve Sizes on Post-TAVI Wall Stresses and Deformations.Journal of clinical medicine · 2025Article
- The impact of bicuspid valve morphology on the selection of transcatheter aortic valve implantation devices: anEuropean heart journal. Imaging methods and practice · 2025Article
- The Application of Precision Medicine in Structural Heart Diseases: A Step towards the Future.Journal of personalized medicine · 2024Review
- Analysis of fibrocalcific aortic valve stenosis: computational pre-and-post TAVR haemodynamics behaviours.Royal Society open science · 2024Article
- Reduced Order Modeling for Real-Time Stent Deformation Simulations of Transcatheter Aortic Valve Prostheses.Annals of biomedical engineering · 2024Article
- Calcium Fracture and Device Over Expansion in Transcatheter Aortic Valve Replacement for Bicuspid Aortic Valves.Annals of biomedical engineering · 2023Article
- Latest Developments in Adapting Deep Learning for Assessing TAVR Procedures and Outcomes.Journal of clinical medicine · 2023Review
- Mild Paravalvular Leak May Pose an Increased Thrombogenic Risk in Transcatheter Aortic Valve Replacement (TAVR) Patients-Insights from Patient Specific In Vitro and In Silico Studies.Bioengineering (Basel, Switzerland) · 2023Article
- Designing a Novel Asymmetric Transcatheter Aortic Valve for Stenotic Bicuspid Aortic Valves Using Patient-Specific Computational Modeling.Annals of biomedical engineering · 2023Article
- Quantity and location of aortic valve calcification predicts paravalvular leakage after transcatheter aortic valve replacement: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Review
- Long-term prognostic impact of paravalvular leakage on coronary artery disease requires patient-specific quantification of hemodynamics.Scientific reports · 2022Article
- Validating In Silico and In Vitro Patient-Specific Structural and Flow Models with Transcatheter Bicuspid Aortic Valve Replacement Procedure.Cardiovascular engineering and technology · 2022Article
- Transcatheter aortic valve replacement for bicuspid aortic valve disease: does conventional surgery have a future?Annals of cardiothoracic surgery · 2022Review
- Biomechanics of Transcatheter Aortic Valve Replacement Complications and Computational Predictive Modeling.Structural heart : the journal of the Heart Team · 2022Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Calcific aortic valve disease (CAVD) is characterized by stiffened aortic valve leaflets. Bicuspid aortic valve (BAV) is the most common congenital heart disease. Transcatheter aortic valve replacement (TAVR) is a treatment approach for CAVD where a stent with mounted bioprosthetic valve is deployed on the stenotic valve. Performing TAVR in calcified BAV patients may be associated with post-procedural complications due to the BAV asymmetrical structure. This study aims to develop refined computational models simulating the deployments of Evolut R and PRO TAVR devices in a representative calcified BAV. The paravalvular leakage (PVL) was also calculated by computational fluid dynamics simulations. Computed tomography scan of severely stenotic BAV patient was acquired. The 3D calcium deposits were generated and embedded inside a parametric model of the BAV. Deployments of the Evolut R and PRO inside the calcified BAV were simulated in five bioprosthesis leaflet orientations. The hypothesis of asymmetric and elliptic stent deployment was confirmed. Positioning the bioprosthesis commissures aligned with the native commissures yielded the lowest PVL (15.7 vs. 29.5 mL/beat). The Evolut PRO reduced the PVL in half compared with the Evolut R (15.7 vs. 28.7 mL/beat). The proposed biomechanical computational model could optimize future TAVR treatment in BAV patients. Graphical abstract.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.