Evidence map›Paper›PMID 31372820›Full record

ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2019

Inhibitory Control Deficits Associated with Upregulation of CB

Ian R Jacobs, Changqing Xu, Douglas J Hermes, Alexis F League, Callie Xu, Bhupendra Nath, Wei Jiang, Micah J Niphakis, Benjamin F Cravatt, Ken Mackie and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Role of Monocyte/Macrophages in the Pathogenesis of NeuroHIV.Results and problems in cell differentiation · 2024
    Review
  11. Effects of acute ΔBrain research · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Emerging Role of Nef in the Development of HIV Associated Neurological Disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021
    Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Ian R JacobsDepartment of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. jacobsir@email.unc.edu.ORCID 0000-0001-5675-5224
Changqing XuDepartment of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Douglas J HermesDepartment of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Alexis F LeagueDepartment of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Callie XuDepartment of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Bhupendra NathDepartment of Chemistry & Biochemistry, North Carolina Central University, Durham, NC, 27707, USA.
Wei JiangDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, 29425, USA.
Micah J NiphakisThe Skaggs Institute for Chemical Biology, Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Benjamin F CravattThe Skaggs Institute for Chemical Biology, Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Ken MackieDepartment of Psychological & Brain Sciences, Indiana University, Bloomington, IN, 47405, USA.
Somnath MukhopadhyayDepartment of Chemistry & Biochemistry, North Carolina Central University, Durham, NC, 27707, USA.
Aron H LichtmanDepartment of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Bogna M Ignatowska-JankowskaNeuronal Rhythms in Movement Unit, Okinawa Institute of Science and Technology, Okinawa, 904-0495, Japan.
Sylvia FittingDepartment of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. sfitting@email.unc.edu.
University of North Carolina at Chapel Hill · USNorth Carolina Central University · USScripps Research Institute · USIndiana University Bloomington · USMedical University of South Carolina · USOkinawa Institute of Science and Technology Graduate University · JPVirginia Commonwealth University · US

Funding

Training on Research in Drug AbuseT32DA007244 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Regina M Carelli · 1990 to 2026
$7.6M
CHEMOPROTEOMIC METHODS FOR SERINE HYDROLASE INHIBITOR DEVELOPMENTR01DA033760 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI CRAVATT, BENJAMIN F, SCAMPAVIA, LOUIS DANIEL · 2012 to 2021
$5.1M
CB1 Allosteric Modulators: Molecular, Cellular and In Vivo PharmacologyR01DA039942 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI KINSEY, STEVEN G., LICHTMAN, ARON H · 2016 to 2020
$2.6M
Endocannabinoid-mediated neuroprotection in models of neuroAIDS in vivoR01DA045596 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FITTING, SYLVIA · 2018 to 2022
$1.9M
Synergistic effect of HIV virions and bacterial LPS on memory B cell apoptosisR01AI091526 · NIAID · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI JIANG, WEI · 2011 to 2015
$1.4M
On the pathogenic role of anti-CD4 antibody in poor CD4+ T cell recovery after antiretroviral therapy in HIV diseaseR01AI128864 · NIAID · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI JIANG, WEI · 2017 to 2021
$1.1M
Mapping HIV-Tat +/- endocannabinoid induced synaptic changes at the macromolecular level via cryo-electron tomographyR21DA045597 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FITTING, SYLVIA, KOURKOUTIS, LENA F · 2018 to 2019
$434k
Investigation of endocannabinoid-mediated neuroprotection in models of neuroAIDSR21DA041903 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FITTING, SYLVIA · 2016 to 2017
$407k
NIAID NIH HHS R01 AI091526NIAID NIH HHS R01 AI128864NIDA NIH HHS R01 DA033760NIDA NIH HHS R01 DA039942NIDA NIH HHS R01 DA045596NIDA NIH HHS R21 DA041903NIDA NIH HHS R21 DA045597NIDA NIH HHS T32 DA007244
6 · The paper itself

Abstract

In the era of combined antiretroviral therapy, HIV-1 infected individuals are living longer lives; however, longevity is met with an increasing number of HIV-1 associated neurocognitive disorders (HAND) diagnoses. The transactivator of transcription (Tat) is known to mediate the neurotoxic effects in HAND by acting directly on neurons and also indirectly via its actions on glia. The Go/No-Go (GNG) task was used to examine HAND in the Tat transgenic mouse model. The GNG task involves subjects discriminating between two stimuli sets in order to determine whether or not to inhibit a previously trained response. Data reveal inhibitory control deficits in female Tat(+) mice (p = .048) and an upregulation of cannabinoid type 1 receptors (CB

Indexed as

Disease Models, AnimalHIV-1Inhibition, PsychologicalAIDS Dementia ComplexAnimalsFemaleLimbic LobeMaleMiceMice, Inbred C57BLMice, TransgenicNeurocognitive DisordersPsychomotor PerformanceReceptor, Cannabinoid, CB1tat Gene Products, Human Immunodeficiency VirusUp-RegulationReceptor, Cannabinoid, CB1tat Gene Products, Human Immunodeficiency VirusCannabinoid receptor type-1EndocannabinoidsFAAH enzyme inhibitionGo/no-go taskInfralimbic cortexTransactivator of transcription

Identifiers

PMID31372820
PMCPMC6898753
OpenAlexW2965310939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.