Evidence map›Paper›PMID 31372803›Full record

Trial reportEuropean journal of applied physiology2019

Twelve weeks of resistance training does not influence peripheral levels of neurotrophic growth factors or homocysteine in healthy adults: a randomized-controlled trial.

Kieran J Marston, Belinda M Brown, Stephanie R Rainey-Smith, Sabine Bird, Linda Wijaya, Shaun Y M Teo, Simon M Laws, Ralph N Martins, Jeremiah J Peiffer

Open access · greenAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Myokines and Resistance Training: A Narrative Review.International journal of molecular sciences · 2022
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kieran J MarstonDepartment of Exercise Science, College of Science, Health, Engineering and Education, Murdoch University, 90 South Street, Murdoch, Perth, WA, 6150, Australia. K.Marston@murdoch.edu.au.
Belinda M BrownDepartment of Exercise Science, College of Science, Health, Engineering and Education, Murdoch University, 90 South Street, Murdoch, Perth, WA, 6150, Australia.
Stephanie R Rainey-SmithAgeing, Cognition and Exercise (ACE) Research Group, Murdoch University, Perth, WA, Australia.
Sabine BirdCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Linda WijayaDepartment of Psychology, College of Science, Health, Engineering and Education, Murdoch University, Perth, WA, Australia.
Shaun Y M TeoDepartment of Exercise Science, College of Science, Health, Engineering and Education, Murdoch University, 90 South Street, Murdoch, Perth, WA, 6150, Australia.
Simon M LawsCollaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Ralph N MartinsCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Jeremiah J PeifferDepartment of Exercise Science, College of Science, Health, Engineering and Education, Murdoch University, 90 South Street, Murdoch, Perth, WA, 6150, Australia.
Murdoch University · AUEdith Cowan University · AUAustralian Alzheimer’s Research Foundation · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThere is growing evidence for a preventative effect of resistance training on cognitive decline through physiological mechanisms; yet, the effect of resistance training on resting growth factors and homocysteine levels is incompletely understood. This study aimed to investigate the effect of intense resistance training, for 12 weeks, on changes in peripheral growth factors and homocysteine in late middle-aged adults.

methods45 healthy adults were enrolled into the single-site parallel groups' randomized-controlled trial conducted at the Department of Exercise Science, Strength and Conditioning Laboratory, Murdoch University. Participants were allocated to the following conditions: (1) high-load resistance training (n = 14), or (2) moderate-load resistance training (n = 15) twice per week for 12 weeks; or (3) non-exercising control group (n = 16). Data were collected from September 2016 to December 2017. Fasted blood samples were collected at baseline and within 7 days of trial completion for the analysis of resting serum brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1, vascular endothelial growth factor, and plasma homocysteine levels.

resultsNo differences in baseline to post-intervention change in serum growth factors or plasma homocysteine levels were observed between groups. A medium effect was calculated for BDNF change within the high-load condition alone (+ 12.9%, g = 0.54).

conclusionsHigh-load or moderate-load resistance training twice per week for 12 weeks has no effect on peripheral growth factors or homocysteine in healthy late middle-aged adults.

trial registrationAustralian New Zealand Clinical Trials Registry: ACTRN12616000690459.

Indexed as

AgedBrain-Derived Neurotrophic FactorFemaleHomocysteineHumansInsulin-Like Growth Factor IMaleMiddle AgedResistance TrainingVascular Endothelial Growth Factor ABrain-Derived Neurotrophic FactorHomocysteineInsulin-Like Growth Factor IVascular Endothelial Growth Factor ACognitive declineGrowth factorsHomocysteinePreventative medicineStrength training

Identifiers

PMID31372803
OpenAlexW2966595963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.