ArticleVirchows Archiv : an international journal of pathology2019
Benign breast papillary lesions diagnosed on core biopsy: upgrade rate and risk factors associated with malignancy on surgical excision.
Article in Virchows Archiv : an international journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Upgrade Rate and Predictive Factors for Breast Benign Intraductal Papilloma Diagnosed at Biopsy: A Meta-Analysis.Annals of surgical oncology · 2021Pooled it
- Microdochectomy for patients with nipple discharge and the risk of associated breast cancer.BMC surgery · 2026Article
- Investigation of Factors Affecting Histopathological Upgrade in Breast Papillary Lesions: A Single-Center Study.Breast care (Basel, Switzerland) · 2026Article
- Intraductal papilloma of the breast: low risk, but handle with care.La Radiologia medica · 2026Article
- To VAE or not to VAE: outcomes of radial scars/complex sclerosing lesions and papillary lesions without atypia in the King's College Hospital breast service (2017-2023).Histopathology · 2026Article
- A Rare Case of Mucinous Carcinoma Arising in Association with an Intraductal Papilloma.Surgical case reports · 2026Article
- Papillary lesions of breast on core-needle biopsy: Factors associated with malignant upgrade on surgical excision.Journal of clinical imaging science · 2026Article
- Management of Breast Intraductal Papilloma Diagnosed on Core Needle Biopsy: Excision or Follow-up?Cureus · 2024Article
- Juvenile Papillomatosis of the Breast: a Report of Two Cases with Review of the literature.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2024Review
- Invasive papillary carcinoma of the breast.Frontiers in oncology · 2024Review
- Clinical Radiologic Analysis of 2964 Papillary Breast Lesions.The breast journal · 2024Article
- Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).Virchows Archiv : an international journal of pathology · 2023Review
- Clinicopathological and Imaging Features of Breast Papillary Lesions and Their Association with Pathologic Nipple Discharge.Diagnostics (Basel, Switzerland) · 2023Article
- [B3 lesions of the breast: histological, clinical, and epidemiological aspects : Update].Pathologie (Heidelberg, Germany) · 2023Review
- Papillary lesions of the breast.Virchows Archiv : an international journal of pathology · 2022Review
- Intraductal Papilloma of the Breast: Prevalence of Malignancy and Natural History Under Active Surveillance.Annals of surgical oncology · 2021Article
- Benign Breast Intraductal Papillomas Without Atypia at Core Needle Biopsies: Is Surgical Excision Necessary?Annals of surgical oncology · 2021Article
- Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Review
- Multimodality approach to the nipple-areolar complex: a pictorial review and diagnostic algorithm.Insights into imaging · 2020Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evaluation of radiologically detected breast lesions is a common task in surgical pathology. Some benign lesions on biopsy are associated with an upgrade to in situ or invasive carcinoma on excision. The non-atypical breast papilloma has published upgrade rates of 0 to 29%. Traditionally, papillomas have been managed surgically, but the wide range of upgrade rates has raised uncertainty about the need for routine surgical excision. This study aims to identify risk factors associated with upgrade and determine the upgrade rate of non-atypical papillomas at our institution. In a retrospective review of pathology reports, we identified 266 patients with a diagnosis of benign papilloma on breast core biopsy. One hundred eighty-two patients underwent surgical resection. The final surgical pathology reports of all patients were reviewed and divided into one of two groups-benign or malignant. Twenty-one patients had a final diagnosis of in situ or invasive carcinoma, resulting in an upgrade rate of 12%. Radiologically detected lesions with calcifications were at higher risk for upgrade (OR = 4.45, 95% CI 1.08-18.27) than lesions without calcifications. Additionally, advanced patient age (OR = 1.07, 95% CI 1.03-1.13) and lesion size greater than 0.5 cm (OR = 2.59, 95% CI 0.38-17.48) was associated with upgrade to malignancy. Routine surgical excision of all papillomas is not recommended. Younger patients without high-risk features may benefit from clinical and radiologic follow-up alone. Accurate risk stratification will spare low-risk women unnecessary surgery.
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