Evidence map›Paper›PMID 31372681›Full record

ReviewPediatric cardiology2019

Tbx3-Mediated Regulation of Cardiac Conduction System Development and Function: Potential Contributions of Alternative RNA Processing.

Brian P Delisle, Yao Yu, Pavan Puvvula, Allison R Hall, Chad Huff, Anne M Moon

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brian P DelisleDepartment of Physiology, University of Kentucky School of Medicine, Lexington, KY, USA.
Yao YuDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Pavan PuvvulaDepartment of Molecular and Functional Genomics, Weis Center for Research, Geisinger Clinic, 100 North Academy Ave 26-18, Danville, PA, 17822, USA.
Allison R HallDepartment of Physiology, University of Kentucky School of Medicine, Lexington, KY, USA.
Chad HuffDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Anne M MoonDepartment of Molecular and Functional Genomics, Weis Center for Research, Geisinger Clinic, 100 North Academy Ave 26-18, Danville, PA, 17822, USA. ammoon@geisinger.edu.

Funding

Tbx3-regulated alternative RNA processing in cardiac conduction system developmentR01HL132397 · NHLBI · GEISINGER CLINIC · PI MOON, ANNE M · 2016 to 2019
$2.6M
NHLBI NIH HHS HL132397NHLBI NIH HHS R01 HL132397
6 · The paper itself

Abstract

In this article, we provide a brief summary of work by us and others to discover the molecular underpinnings of early conduction system development and function. We focus on how the multifunctional protein Tbx3 contributes to acquisition and homeostasis of the tissue-specific properties of the sinoatrial and atrioventricular nodes. We also provide unpublished, preliminary findings supporting the role of Tbx3-regulated alternative RNA processing in the developing conduction system.

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsAtrioventricular NodeGene ExpressionHeart Conduction SystemHumansRNAT-Box Domain ProteinsRNAT-Box Domain ProteinsTBX3 protein, humanTbx3 protein, mouseChannelopathiesConduction systemDevelopmentTbx3

Identifiers

PMID31372681

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.