Evidence map›Paper›PMID 31372585›Full record

ArticleJBMR plus2019

The Osteocyte Transcriptome Is Extensively Dysregulated in Mouse Models of Osteogenesis Imperfecta.

Sarah M Zimmerman, Milena Dimori, Melissa E Heard-Lipsmeyer, Roy Morello

Open access · goldAbstract read
In one paragraph

Article in JBMR plus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Cells · 2025
    Article
  4. A new Col1a1 conditional knock-in mouse model to study osteogenesis imperfecta.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Article
  5. Update on the Genetics of Osteogenesis Imperfecta.Calcified tissue international · 2024
    Review
  6. Review
  7. Review
  8. Biosynthesized Silver Nanoparticles fromCurrent pharmaceutical biotechnology · 2024
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. 4-PBA Treatment Improves Bone Phenotypes in the Aga2 Mouse Model of Osteogenesis Imperfecta.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Article
  19. The osteocyte as a signaling cell.Physiological reviews · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sarah M ZimmermanDepartment of Physiology and Biophysics University of Arkansas for Medical Sciences Little Rock AR USA.
Milena DimoriDepartment of Physiology and Biophysics University of Arkansas for Medical Sciences Little Rock AR USA.
Melissa E Heard-LipsmeyerDepartment of Physiology and Biophysics University of Arkansas for Medical Sciences Little Rock AR USA.
Roy MorelloDepartment of Physiology and Biophysics University of Arkansas for Medical Sciences Little Rock AR USA.
University of Arkansas for Medical Sciences · US

Funding

Understanding the Negative Prognostic Impact of Intraosseous Focal Lesions in Multiple MyelomaP20GM125503 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI CHARLES A O'BRIEN · 2018 to 2026
$23.0M
Role of the Leprecan Genes in Skeletal FormationR01AR060823 · NIAMS · UNIV OF ARKANSAS FOR MED SCIS · PI MORELLO, ROY · 2012 to 2016
$1.6M
NIAMS NIH HHS R01 AR060823NIGMS NIH HHS P20 GM125503
6 · The paper itself

Abstract

Osteocytes are long-lived, highly interconnected, terminally differentiated osteoblasts that reside within mineralized bone matrix. They constitute about 95% of adult bone cells and play important functions including in the regulation of bone remodeling, phosphate homeostasis, and mechanical stimuli sensing and response. However, the role of osteocytes in the pathogenesis of congenital diseases of abnormal bone matrix is poorly understood. This study characterized in vivo transcriptional changes in osteocytes from

Indexed as

COLLAGENGENETIC ANIMAL MODELSOSTEOCYTESOSTEOGENESIS IMPERFECTARNASEQ

Identifiers

PMID31372585
PMCPMC6659450
OpenAlexW2913673823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.